{"product_id":"rfwd3-antibody-cat-csb-pa041555","title":"RFWD3 Antibody - Cat. #: CSB-PA041555","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:BC027246 antibody; E3 ubiquitin protein ligase RFWD3 antibody; E3 ubiquitin-protein ligase RFWD3 antibody; FLJ10520 antibody; MGC27888 antibody; RFWD3 antibody; RFWD3_HUMAN antibody; Ring finger and WD repeat domain 3 antibody; RING finger and WD repeat domain containing protein 3 antibody; RING finger and WD repeat domain-containing protein 3 antibody; RING finger protein 201 antibody; RNF201 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q6PCD5\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Synthesized peptide derived from internal of Human RFWD3.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; WB:1:500-1:3000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:E3 ubiquitin-protein ligase that mediates the ubiquitination of p53\/TP53 in the late response to DNA damage, and acts as a positive regulator of p53\/TP53 stability, thereby regulating the G1\/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53\/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53\/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53\/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.\u003cbr\u003e\u003cbr\u003eThe MGC Project Team, Genome Res. 14:2121-2127(2004).\u003cbr\u003eOta T., Nat. Genet. 36:40-45(2004).\u003cbr\u003eMatsuoka S., Science 316:1160-1166(2007).\u003cbr\u003e\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:RFWD3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Others\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483756834916,"sku":"CSB-PA041555","price":727.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_45fc083a-f006-4181-a59d-f4b48cc23a28.jpg?v=1660075511","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/rfwd3-antibody-cat-csb-pa041555","provider":"GeneBio ","version":"1.0","type":"link"}