{"product_id":"recombinant-mouse-cd64-fcgr1-protein-his-avi-tag-biotinylated","title":"Recombinant Mouse CD64\/FCGR1 Protein (His\u0026AVI Tag), Biotinylated","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: AI323638;AV092959;CD64;FcgammaRI;IGGHAFC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: Biotinylated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: HEK293 Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-His-Avi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P26151\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_034316.1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: High affinity immunoglobulin  gamma Fc receptor I, also known as FCGR1 and CD64, is an integral  membraneglycoprotein and a member of the immunoglobulin superfamily. CD64  is a high affinity receptor for the Fc region of IgG gamma and functions in  both innate and adaptive immune responses. Receptors that recognize the Fc  portion of IgG function in the regulation of immune response and are divided  into three classes designated CD64, CD32, and CD16. CD64 is structurally  composed of asignal peptidethat allows its transport to the surface  of a cell, threeextracellularimmunoglobulin domainsof the  C2-type that it uses to bind antibody, a hydrophobictransmembrane domain,  and a short cytoplasmic tail. CD64 isconstitutivelyfound on only  macrophages and monocytes, but treatment of polymorphonuclear  leukocyteswith cytokines likeIFNγandG-CSFcan  induce CD64 expression on these cells. The inactivation of the mouse CD64  resulted in a wide range of defects in antibody Fc-dependent functions. Mouse  CD64 is an early participant in Fc-dependent cell activation and in the  development of immune responses.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: 1. Immobilized Rituximab (IgG1) at 1 μg\/mL can bind Biotinylated Mouse CD64 recombinant protein, the EC50 is 20-50 ng\/mL. 2. Labeling ratio of biotin to protein is 0.7-1 by the HABA assay. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Pro 297\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 34.3 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 50-55 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47986112135268,"sku":"PKSM040877","price":1743.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_082d7171-ce2e-4d25-8b3b-86f82d81a888.jpg?v=1772482175","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/recombinant-mouse-cd64-fcgr1-protein-his-avi-tag-biotinylated","provider":"GeneBio ","version":"1.0","type":"link"}