{"product_id":"recombinant-human-respiratory-syncytial-virus-rsv-a-rsb1734-glycoprotein-g-rsv-g-protein-93-homology-his-tag","title":"Recombinant Human Respiratory Syncytial Virus (RSV) (A, rsb1734) Glycoprotein G\/RSV-G Protein (93% Homology) (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Viral Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: G Protein;RSV\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: RSV\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: HEK293 Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P27022\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: P27022-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Human respiratory syncytial virus  (HRSV) is the most common etiological agent of acute lower respiratory tract  disease in infants and can cause repeated infections throughout life. It is  classified within the genus pneumovirus of the family paramyxoviridae. Like  other members of the family, HRSV has two major surface glycoproteins (G and F)  that play important roles in the initial stages of the infectious cycle. HRSV G  protein is a type II glycoprotein of 289-299 amino acids (depending on the  virus strain) with a signal\/anchor hydrophobic domain and is extensively  modified by the addition of both N-and O-linked oligosaccharides to achieve the  mature form of 80-90 kDa. The C-terminal ectodomain of the G protein has a  central region and four cysteines which are conserved in all HRSV isolates and  have been proposed as the putative receptor binding site. The G protein  mediates attachment of the virus to the host cell membrane by interacting with  heparan sulfate, initiating the infection. As similar to mucins in amino acid  compositions, the RSV G protein can interact with host CX3CR1, the receptor for  the CX3C chemokine fractalkine, and thus modulates the immune response and  facilitate infection. Secreted glycoprotein G helps RSV escape  antibody-dependent restriction of replication by acting as an antigen decoy and  by modulating the activity of leukocytes bearing Fcgamma receptors. Unlike the  other paramyxovirus attachment proteins, HRSV-G lacks both neuraminidase and  hemagglutinating activities.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Asn 66-Arg297\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 26.3 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 60-90 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47978855891044,"sku":"PKSH031973","price":1726.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_50957dd9-4fe6-45bd-9ccd-f47c1ba9c38f.jpg?v=1772293833","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/recombinant-human-respiratory-syncytial-virus-rsv-a-rsb1734-glycoprotein-g-rsv-g-protein-93-homology-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}