{"product_id":"recombinant-human-ptx3-pentraxin-3-tsg-14-protein-his-tag","title":"Recombinant Human PTX3\/Pentraxin 3\/TSG-14 Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: PTX3;TNFAIP5;TSG-14\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Cardiovascular;Cancer;immunology\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: HEK293 Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P26022\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_002843.2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Pentraxin-related protein PTX3, also  known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis  factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted  protein which contains onepentaxin domain. PTX3 plays a role in the  regulation of innate resistance to pathogens, inflammatory reactions, possibly  clearance of self-components and female fertility. Pentraxins are a family of  evolutionarily conserved multifunctional pattern-recognition proteins  characterized by a cyclic multimeric structure. Based on the primary structure  of the subunit, the pentraxins are divided into two groups: short pentraxins  and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component  (SAP) are the two short pentraxins. The prototype protein of the long pentraxin  group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in  response to IL-6, while PTX3 is produced by a variety of tissues and cells and  in particular by innate immunity cells in response to proinflammatory signals  and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility  by acting as a nodal point for the assembly of the cumulus oophorus  hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands,  including growth factors, extracellular matrix components and selected  pathogens, playing a role in complement activation and facilitating pathogen  recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also  contribute to the pathogenesis of atherosclerosis.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Ser 381\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 41.6 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 43-47 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972858396772,"sku":"PKSH030911","price":1031.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_1dffd677-a22a-4aa8-a8d1-2a2d0f4ccc55.jpg?v=1772200844","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/recombinant-human-ptx3-pentraxin-3-tsg-14-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}