{"product_id":"recombinant-human-lamtor2-robld3-mapbpip-protein-his-tag","title":"Recombinant Human LAMTOR2\/ROBLD3\/MAPBPIP Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: ENDAP;HSPC003;MAPBPIP;MAPKSP1AP;ROBLD3;RP11-336K24.9;Ragulator2;p14\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q9Y2Q5\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: Q9Y2Q5-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Ragulator  complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late  endosomal \/ lysosomal Mp1-interacting protein, Late endosomal \/ lysosomal  adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding  protein-interacting protein, Roadblock domain-containing protein 3, LAMTOR2,  MAPBPIP and ROBLD3, is a protein which belongs to theGAMAD family.  LAMTOR2 \/ ROBLD3 is a regulator of the TOR pathway, a signaling cascade that  promotes cell growth in response to growth factors, energy levels, and amino  acids. As part of the Ragulator complex, LAMTOR2 \/ ROBLD3 recruits the Rag  GTPases and the mTORC1 complex to lysosomes, a key step in activation of the  TOR signaling cascade by amino acids. LAMTOR2 \/ ROBLD3 is an adapter protein  that enhances the efficiency of the MAP kinase cascade facilitating the  activation of MAPK2. Defects in LAMTOR2 are the cause of immunodeficiency due  to defect in MAPBP-interacting protein (ID-MAPBPIP). This form of primary  immunodeficiency syndrome includes congenital neutropenia, partial albinism,  short stature and B-cell and cytotoxic T-cell deficiency.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Ser 125\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 15 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 13 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972848304228,"sku":"PKSH030802","price":1152.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_998b9745-db0d-43d6-8209-4d56e2eab768.jpg?v=1772200268","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/recombinant-human-lamtor2-robld3-mapbpip-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}