{"product_id":"recombinant-human-c-c-motif-chemokine-18-ccl18-active","title":"Recombinant Human C-C motif chemokine 18 (CCL18) (Active)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:100ug. Other sizes are also available. Please contact us. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Immunology\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniprot NO.\u003c\/b\u003e:P55774\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniprot Entry Name\u003c\/b\u003e:CCL18_HUMAN\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene Names\u003c\/b\u003e:CCL18,AMAC1,DCCK1,MIP4,PARC,SCYA18\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSource\u003c\/b\u003e:E.Coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Region\u003c\/b\u003e:21-89aa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e:AQVGTNKELC CLVYTSWQIP QKFIVDYSET SPQCPKPGVI LLTKRGRQIC ADPNKKWVQK YISDLKLNA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProtein Description\u003c\/b\u003e:Full Length of Mature Protein\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTag Info\u003c\/b\u003e:Tag-Free\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMol. Weight\u003c\/b\u003e:7.9 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBiological_Activity\u003c\/b\u003e:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 1.0-10 ng\/ml.\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:\u0026gt;97% as determined by SDS-PAGE and HPLC.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:Less than 1.0 EU\/µg as determined by LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Lyophilized powder\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Lyophilized from a 0.2 ?m filtered concentrated solution in 20 mM PB, pH 7.4, 100 mM NaCl.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg\/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?\/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eNotes\u003c\/b\u003e:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAlternative Name\/ Alias\u003c\/b\u003e:Alternative macrophage activation-associated CC chemokine 1, CC chemokine PARC, Dendritic cell chemokine 1, DC-CK1, Macrophage inflammatory protein 4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRelevance\u003c\/b\u003e:Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. {ECO:0000269|PubMed:11745396, ECO:0000269|PubMed:11978786}.\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePubMed ID\u003c\/b\u003e:9233607; 9570561; 9192897; 10049593; 10087196; 19054851; 15489334; 9129202; 11745396; 11978786; 23742785\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFunction\u003c\/b\u003e:Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eInvolvement in disease\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSubcellular Location\u003c\/b\u003e:Secreted\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProtein Families\u003c\/b\u003e:Intercrine beta (chemokine CC) family\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTissue Specificity\u003c\/b\u003e:Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. \u003c\/p\u003e\u003cp\u003e\u003cb\u003ePaythway\u003c\/b\u003e:Chemokinesignalingpathway\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHGNC Database Link\u003c\/b\u003e:https:\/\/www.genenames.org\/cgi-bin\/gene_symbol_report?hgnc_id=HGNC:10616\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniGene Database Link\u003c\/b\u003e:https:\/\/www.ncbi.nlm.nih.gov\/UniGene\/clust.cgi?ORG=Hs\u0026amp;CID=143961\u003c\/p\u003e\u003cp\u003e\u003cb\u003eKEGG Database Link\u003c\/b\u003e:https:\/\/www.genome.jp\/dbget-bin\/www_bget?hsa:6362\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSTRING Database Link\u003c\/b\u003e:https:\/\/string-db.org\/network\/9606.ENSP00000004921\u003c\/p\u003e\u003cp\u003e\u003cb\u003eOMIM Database Link\u003c\/b\u003e:https:\/\/www.omim.org\/entry\/603757603757603757\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40529894309988,"sku":"CSB-AP000621HU","price":1380.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_ff788e8c-b707-444c-883e-9067b9d4da8d.jpg?v=1661105666","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/recombinant-human-c-c-motif-chemokine-18-ccl18-active","provider":"GeneBio ","version":"1.0","type":"link"}