{"product_id":"recombinant-calloselasma-rhodostoma-snaclec-rhodocytin-subunit-alpha","title":"Recombinant Calloselasma rhodostoma Snaclec rhodocytin subunit alpha","description":"\u003cp\u003e\u003cb\u003e\u0026gt;Several Other Sizes Are Also Available. Please Inquire.  Default Size\u003c\/b\u003e: 200ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUpdated Date\u003c\/b\u003e: Stock Protein updated on 20170405\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch areas\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget \/ Protein\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eBiologically active\u003c\/b\u003e: Not Tested\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression system\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies of origin\u003c\/b\u003e: Calloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDelivery time\u003c\/b\u003e: 3-7 business days\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniprot ID\u003c\/b\u003e: Q9I841\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAA Sequence\u003c\/b\u003e: GLEDCDFGWSPYDQHCYQAFNEQKTWDEAEKFCRAQENGAHLASIESNGEADFVSWLISQKDELADEDYVWIGLRAQNKEQQCSSEWSDGSSVSYENLIDLHTKKCGALEKLTGFRKWVNYYCEQMHAFVCKLLPY\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTag info\u003c\/b\u003e: N-terminal 6xHis-SUMO-tagged\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Region\u003c\/b\u003e: 1-136aa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProtein length\u003c\/b\u003e: Full Length\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMW\u003c\/b\u003e: 31.8 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAlternative Name(s)\u003c\/b\u003e: Aggretin alpha chain\nRhodoaggretin subunit alpha\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRelevance\u003c\/b\u003e: Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B\/CLEC2). Binding leads to tyrosine phosphorylation in the Cytoplasmic domain tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLC-gamma-2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha-2\/beta-1 (ITGA2\/ITGB1) may also induce aggregation, but this is controversial.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReference\u003c\/b\u003e: \"Aggretin, a heterodimeric C-type lectin from Calloselasma rhodostoma (malayan pit viper), stimulates platelets by binding to alpha 2beta 1 integrin and glycoprotein Ib, activating Syk and phospholipase Cgamma 2, but does not involve the glycoprotein VI\/Fc receptor gamma chain collagen receptor.\"Navdaev A., Clemetson J.M., Polgar J., Kehrel B.E., Glauner M., Magnenat E., Wells T.N.C., Clemetson K.J.J. Biol. Chem. 276:20882-20889(2001).\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e: Greater than 90% as determined by SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. \nGenerally, the shelf life of liquid form is 6 months at -20℃\/-80℃. The shelf life of lyophilized form is 12 months at -20℃\/-80℃.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eNotes\u003c\/b\u003e: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":39766632497252,"sku":"CSB-EP888242CBG","price":1244.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_33d57337-e02c-4a00-ad80-eb1b001dc663.jpg?v=1659192319","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/recombinant-calloselasma-rhodostoma-snaclec-rhodocytin-subunit-alpha","provider":"GeneBio ","version":"1.0","type":"link"}