{"product_id":"rbbp6-antibody-biotin-conjugated-cat-csb-pa768776ld01hu","title":"RBBP6 Antibody, Biotin conjugated - Cat. #: CSB-PA768776LD01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:DKFZp686P0638 antibody; DKFZp761B2423 antibody; E3 ubiquitin-protein ligase RBBP6 antibody; MY038 antibody; P2P R antibody; P2PR antibody; p53 associated cellular protein of testis antibody; p53-associated cellular protein of testis antibody; p53-associated cellular protein, testis-derived antibody; PACT antibody; Proliferation potential related protein antibody; Proliferation potential-related protein antibody; Protein P2P R antibody; Protein P2P-R antibody; Protein P2PR antibody; Protein RBQ 1 antibody; Protein RBQ1 antibody; RB binding protein 6, ubiquitin ligase antibody; RB binding Q protein 1 antibody; RBBP 6 antibody; Rbbp6 antibody; RBBP6_HUMAN antibody; RBQ 1 antibody; RBQ-1 antibody; RBQ1 antibody; Retinoblastoma binding protein 6 isoform 3 antibody; Retinoblastoma binding Q protein 1 antibody; Retinoblastoma-binding protein 6 antibody; Retinoblastoma-binding Q protein 1 antibody; SNAMA antibody; SNAMA, Drosophila, homolog of antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q7Z6E9\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human E3 ubiquitin-protein ligase RBBP6 protein (51-97AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53\/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53\/TP53; may function as negative regulator of p53\/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Biotin\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:RBBP6\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cancer; Cell biology\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486717718628,"sku":"CSB-PA768776LD01HU","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_fccb8505-0ecc-483c-9ff6-0d58601865c1.jpg?v=1660151959","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/rbbp6-antibody-biotin-conjugated-cat-csb-pa768776ld01hu","provider":"GeneBio ","version":"1.0","type":"link"}