{"product_id":"phospho-pdcd4-ser67-antibody-cat-csb-pa047784","title":"Phospho-PDCD4 (Ser67) Antibody - Cat. #: CSB-PA047784","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Death up-regulated gene protein antibody; Dug antibody; H731 antibody; Ma3 antibody; MGC33046 antibody; MGC33047 antibody; Neoplastic transformation inhibitor antibody; Neoplastic transformation inhibitor protein antibody; Nuclear antigen H731 antibody; Nuclear antigen H731 like antibody; Nuclear antigen H731 like protein antibody; Nuclear antigen H731-like antibody; PDCD 4 antibody; Pdcd4 antibody; PDCD4_HUMAN antibody; Programmed cell death 4  antibody; programmed cell death 4 (neoplastic transformation inhibitor) antibody; Programmed cell death protein 4 antibody; Protein 197\/15a antibody; Protein MA-3 antibody; Tis antibody; Topoisomerase-inhibitor suppressed protein antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q53EL6\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around phosphorylation site of serine 67 (K-N-S(p)-S-R) derived from Human PDCD4 .\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; WB:1:500-1:1000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003eInhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA\u003cbr\u003e\u003cbr\u003eKakade D, Islam N, Maeda N, Adegoke OA (2014)BMC Cell Biol 15, 2 .                                        Dorrello NV, et al. (2006)Science 314, 467-71.                Palamarchuk A, et al. (2005)Cancer Res 65, 11282-6.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:PDCD4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling;Cancer;Cell biology\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484025434212,"sku":"CSB-PA047784","price":885.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_9e92d977-d709-4119-82ee-5db5a3177f47.jpg?v=1660086328","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/phospho-pdcd4-ser67-antibody-cat-csb-pa047784","provider":"GeneBio ","version":"1.0","type":"link"}