{"product_id":"human-cystic-fibrosis-transmembrane-conductance-regulator-cftr-elisa-kit","title":"Human Cystic Fibrosis Transmembrane Conductance Regulator, CFTR ELISA Kit","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:96 Tests-1 Kit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Epithelial ion Channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed: 26823428). Mediates the transport of chloride ions across the cell membrane (PubMed: 10792060, PubMed: 11524016, PubMed: 11707463, PubMed: 12519745, PubMed: 15010471, PubMed: 12588899, PubMed: 17036051, PubMed: 19398555, PubMed: 19621064, PubMed: 22178883, PubMed: 25330774, PubMed: 1712898, PubMed: 8910473, PubMed: 9804160, PubMed: 12529365, PubMed: 17182731, PubMed: 26846474, PubMed: 28087700). Channel activity is coupled to ATP hydrolysis (PubMed: 8910473). The ion Channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed: 15010471, PubMed: 19019741). Exerts its function also by modulating the activity of other ion Channels and transporters (PubMed: 12403779, PubMed: 22178883, PubMed: 22121115, PubMed: 27941075). Plays an important role in airway fluid homeostasis (PubMed: 16645176, PubMed: 19621064, PubMed: 26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed: 14668433, PubMed: 16645176, PubMed: 26823428). Modulates the activity of the epithelial sodium Channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed: 17434346, PubMed: 27941075, PubMed: 17182731). Inhibits the activity of the ENaC Channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed: 17182731). Inhibits the activity of the ENaC Channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC Channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed: 27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed: 12403779). Can inhibit the chloride Channel activity of ANO1 (PubMed: 22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed: 19923167, PubMed: 27714810).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e:Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget_protein\u003c\/b\u003e:CFTR\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay type\u003c\/b\u003e:Sandwich\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSensitivity\u003c\/b\u003e:9.28ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDetection range\u003c\/b\u003e:20-3800ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSample type\u003c\/b\u003e:Serum, plasma or other biological fluids\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFull product name\u003c\/b\u003e:Cystic Fibrosis Transmembrane Conductance Regulator\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:2-8ºC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay time\u003c\/b\u003e:1h 30m\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt accession\u003c\/b\u003e:P13569\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMASS(Da)\u003c\/b\u003e:168,142\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGeneID\u003c\/b\u003e:1080\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:ATP-binding cassette sub-family C member 7;cAMP-dependent chloride Channel;CFTR;Channel conductance-controlling ATPase;Cystic fibrosis transmembrane conductance regulator\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene names\u003c\/b\u003e:CFTR\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStandard solution\u003c\/b\u003e:4000ng\/L\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48648095596644,"sku":"E4110hu","price":847.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_958411f5-ee36-40cb-8a7b-4cd61dae4a34.jpg?v=1782708528","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/human-cystic-fibrosis-transmembrane-conductance-regulator-cftr-elisa-kit","provider":"GeneBio ","version":"1.0","type":"link"}