{"product_id":"g3bp1-ab-232-antibody-cat-csb-pa057449","title":"G3BP1 (Ab-232) Antibody - Cat. #: CSB-PA057449","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:ATP dependent DNA helicase VIII antibody; ATP-dependent DNA helicase VIII antibody; G3BP antibody; G3BP stress granule assembly factor 1 antibody; G3BP-1 antibody; G3bp1 antibody; G3BP1_HUMAN antibody; GAP binding protein antibody; GAP SH3 domain binding protein 1 antibody; GAP SH3 domain-binding protein 1 antibody; GTPase activating protein (SH3 domain) binding protein 1 antibody; hDH VIII antibody; Human DNA helicase VIII antibody; MGC111040 antibody; Ras GTPase activating protein binding protein 1 antibody; Ras GTPase activating protein SH3 domain binding protein  antibody; Ras GTPase-activating protein-binding protein 1 antibody; RasGAP associated endoribonuclease G3BP  antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q13283\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around aa.230~234 (S-S-S-P-A) derived from Human G3BP-1.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA\/DNA, RNA\/DNA, and RNA\/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.\u003cbr\u003e\u003cbr\u003eTao WA, et al. (2005) Nat Methods. 2 (8): 591-598.\u003cbr\u003eZheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730.\u003cbr\u003eBeausoleil SA, et al. (2004) Proc Natl Acad Sci USA.101 (33): 12130-12135.\u003cbr\u003eTourrihre H, et al. (2003) J Cell Biol.160 (6): 823-831.\u003cbr\u003e\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Supplied at 1.0mg\/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:G3BP1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483779248228,"sku":"CSB-PA057449","price":731.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_de80b38f-28e5-4b27-9f68-17347ff8a2b7.jpg?v=1660076020","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/g3bp1-ab-232-antibody-cat-csb-pa057449","provider":"GeneBio ","version":"1.0","type":"link"}