{"product_id":"aurkc-antibody-cat-csb-pa002460la01hu","title":"AURKC Antibody - Cat. #: CSB-PA002460LA01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:AURKC antibody; AIE 2 antibody; Aie1 antibody; AIE2 antibody; AIK 3 antibody; AIK3 antibody; ARK 3 antibody; ARK-3 antibody; ARK3 antibody; Aur C antibody; AurC antibody; Aurkc antibody; AURKC_HUMAN antibody; aurora 3 antibody; Aurora C antibody; Aurora kinase C antibody; aurora related kinase 3 antibody; Aurora-related kinase 3 antibody; Aurora\/Ipl1 related kinase 3 antibody; Aurora\/Ipl1-related kinase 3 antibody; Aurora\/Ipl1\/Eg2 protein 2 antibody; EC 2.7.11.1 antibody; Serine threonine protein kinase 13 antibody; serine\/threonine kinase 13 (aurora\/IPL1 like) antibody; serine\/threonine protein kinase aurora C antibody; Serine\/threonine-protein kinase 13 antibody; Serine\/threonine-protein kinase aurora-C antibody; SPGF5 antibody; STK13 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q9UQB9\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Aurora kinase C protein (12-143AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Serine\/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at \\\\\\'Ser-10\\\\\\' and \\\\\\'Ser-28\\\\\\'. AURKC phosphorylates the CPC complex subunits BIRC5\/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at \\\\\\'Ser-228\\\\\\'.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:AURKC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cell biology\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486984417380,"sku":"CSB-PA002460LA01HU","price":409.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_37fd0a24-f428-4c1f-ac7b-82792630feb9.jpg?v=1660157088","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/aurkc-antibody-cat-csb-pa002460la01hu","provider":"GeneBio ","version":"1.0","type":"link"}