{"product_id":"zap70-ab-319-antibody-cat-csb-pa181899","title":"ZAP70 (Ab-319) Antibody - Cat. #: CSB-PA181899","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:70 kDa zeta associated protein antibody; 70 kDa zeta-associated protein antibody; EC 2.7.10.2 antibody; FLJ17670 antibody; FLJ17679 antibody; Selective T cell defect antibody; SRK antibody; STD antibody; Syk related tyrosine kinase antibody; Syk-related tyrosine kinase antibody; Truncated ZAP kinase antibody; Tyrosine protein kinase ZAP70 antibody; Tyrosine-protein kinase ZAP-70 antibody; TZK antibody; ZAP 70 antibody; ZAP70 antibody; ZAP70_HUMAN antibody; Zeta chain associated protein kinase 70kD antibody; Zeta chain associated protein kinase 70kDa antibody; Zeta chain associated protein kinase 70kDa isoform 1 antibody; Zeta chain associated protein kinase 70kDa isoform 2 antibody; Zeta chain of T cell receptor associated protein kinase 70 antibody; Zeta chain TCR associated protein kinase 70kD antibody; Zeta chain TCR associated protein kinase 70kDa antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P43403\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around aa.317~321 (S-P-Y-S-D) derived from Human ZAP70.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003eZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain, which can mediate the transduction of extracellular stimuli into cellular effector functions \u003cbr\u003e\u003cbr\u003eSalomon AR, et al. (2003) Proc Natl Acad Sci U S A; 100(2): 443-448 \u003cbr\u003eKu GM, et al. (2001) EMBO J; 20(3): 457-465 \u003cbr\u003eTang J, et al. (1999) Proc Natl Acad Sci U S A; 96(17): 9775-9780 \u003cbr\u003eZhao Q, et al. (1996) Mol Cell Biol; 16(12): 6765-6774 \u003cbr\u003eWilliams BL, et al. (1999) EMBO J; 18(7): 1832-1844 \u003cbr\u003eAdjali O, et al. (2005) J Clin Invest; 115(8): 2287-2295.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Supplied at 1.0mg\/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:ZAP70\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Tags \u0026amp; Cell Markers?Immunology;Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483780657252,"sku":"CSB-PA181899","price":110100.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_8d8021a1-e6d4-44b4-85f0-28de1b3f7030.jpg?v=1660076062","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/zap70-ab-319-antibody-cat-csb-pa181899","provider":"GeneBio ","version":"1.0","type":"link"}