{"product_id":"smc1a-ab-957-antibody-cat-csb-pa775738","title":"SMC1A (Ab-957) Antibody - Cat. #: CSB-PA775738","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Chromosome segregation protein SmcB antibody; DXS423E antibody; KIAA0178 antibody; MGC138332 antibody; Sb1.8 antibody; Segregation of mitotic chromosomes 1 antibody; SMC protein 1A antibody; SMC-1-alpha antibody; SMC-1A antibody; SMC1 (structural maintenance of chromosomes 1 yeast) like 1 antibody; SMC1 antibody; SMC1 structural maintenance of chromosomes 1 like 1 antibody; SMC1A antibody; SMC1A_HUMAN antibody; SMC1alpha antibody; SMC1L1 antibody; SMCB antibody; Structural maintenance of chromosomes 1A antibody; Structural maintenance of chromosomes protein 1A antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q14683\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around aa. 955~959 (G-S-S-Q-G) derived from Human SMC1.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM\/NBS1 branch and in the ATR\/MSH2 branch of S-phase checkpoint. \u003cbr\u003e\u003cbr\u003eYang XM. et al. (2004) Mol Cell Biol. 24(12): 5290-5303.\u003cbr\u003eKim ST. et al. (2002) Genes Dev. 16(5): 560-570.\u003cbr\u003eRevenkova E.et al. (2001) Mol Cell Biol. 21(20): 6984-6998\u003cbr\u003e\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Supplied at 1.0mg\/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:SMC1A\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling;Cell biology\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483781247076,"sku":"CSB-PA775738","price":110200.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_8c695ffb-62b3-4603-9eac-5ff49fea03e2.jpg?v=1660076079","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/smc1a-ab-957-antibody-cat-csb-pa775738","provider":"GeneBio ","version":"1.0","type":"link"}