{"product_id":"sirpa-antibody-cat-csb-pa973893","title":"SIRPA Antibody - Cat. #: CSB-PA973893","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Signal regulatory protein alpha type 1 antibody; Bit antibody; Brain Ig like molecule with tyrosine based activation motifs antibody; Brain Ig-like molecule with tyrosine-based activation motifs antibody; Brain immunoglobulin like molecule with tyrosine based activation motifs antibody; CD172 antigen like family member A antibody; CD172 antigen-like family member A antibody; CD172a antibody; CD172a antigen antibody; Inhibitory receptor SHPS-1 antibody; Macrophage fusion receptor antibody; MFR antibody; MYD 1 antibody; Myd 1 antigen antibody; MyD-1 antigen antibody; p84 antibody; Protein tyrosine phosphatase non receptor type substrate 1 antibody; PTPNS1 antibody; SHP substrate 1 antibody; SHPS-1 antibody; SHPS1 antibody; SHPS1_HUMAN antibody; Signal regulatory protein alpha 2 antibody; Signal regulatory protein alpha 3 antibody; Signal regulatory protein alpha antibody; Signal regulatory protein alpha type 2 antibody; Signal-regulatory protein alpha-1 antibody; Signal-regulatory protein alpha-2 antibody; Signal-regulatory protein alpha-3 antibody; SIRP antibody; Sirp-alpha-1 antibody; Sirp-alpha-2 antibody; Sirp-alpha-3 antibody; SIRPA antibody; SIRPalpha antibody; SIRPalpha1 antibody; SIRPalpha2 antibody; SIRPalpha3 antibody; Tyrosine phosphatase SHP substrate 1 antibody; Tyrosine protein phosphatase non receptor type substrate 1 antibody; Tyrosine-protein phosphatase non-receptor type substrate 1 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P78324\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Synthesized peptide derived from Human SIRP-alpha1.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.\u003cbr\u003e\u003cbr\u003eKentaro Ide, PNAS, Mar 2007; 104: 5062 - 5066. \u003cbr\u003eThomas T. Chen, Cancer Res., Jan 2004; 64: 117 - 127. \u003cbr\u003eShu Q. Liu, J. Biol. Chem., Nov 2005; 280: 39294 - 39301. \u003cbr\u003eGurpreet S. Kapoor, Cancer Res., Sep 2004; 64: 6444 - 6452. \u003cbr\u003e\u003cbr\u003e\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:SIRPA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Neuroscience;Cardiovascular;Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484001611876,"sku":"CSB-PA973893","price":110100.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_1673438c-8ccb-470b-bb4a-9e4a6103ed16.jpg?v=1660085851","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/sirpa-antibody-cat-csb-pa973893","provider":"GeneBio ","version":"1.0","type":"link"}