{"product_id":"recombinant-phospho-histone-h3-thr45-monoclonal-antibody","title":"Recombinant Phospho-Histone H3 (Thr45) Monoclonal Antibody","description":"\u003cp\u003e\u003cb\u003eSize:\u003c\/b\u003e:50μL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:Store at -20℃ Valid for 12 months. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e:Ice bag\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e:12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e:Primary Antibodies\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e:Monoclonal Antibodies;Recombinant Antibodies;Acetyl\/Phospho\/Methyl Antibodies\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e:Phospho-Histone H3 (Thr45)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e:Histone H;H3C;H3\/A;H3C2;H3C3;H3C4;H3C6;H3C7;H3C8;H3FA;H3C10;H3C11;H3C12;HIST1H3A;H3C1;Histone H3.1;Histone H3\/a;Histone H3\/b;H3FL;HIST1H3B;H3FC;HIST1H3C;H3FB;HIST1H3D;H3FD;HIST1H3E;H3FI;HIST1H3F;H3FH;HIST1H3G;H3FK;HIST1H3H;H3FF;HIST1H3I;H3FJ;HIST1H3J;H3\/A;H3FA;H3FB;H3FC;H3FD;H3FF;H3FH;H3FI;H3FJ;H3FK;H3FL;Hist1h3a;HIST1H3B;HIST1H3C;HIST1H3D;HIST1H3E;HIST1H3F;HIST1H3G;HIST1H3H;HIST1H3I;HIST1H3J;Histone H3.1;Histone H3\/a;Histone H3\/b;H3 histone family;H31;H3a;histone 1;Histone cluster 1;Histone H3\/c;Histone H3\/d;Histone H3\/f;Histone H3\/h;Histone H3\/i;Histone H3\/j;Histone H3\/k;Histone H3\/l;member A\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling;Isotype;Loading Controls\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e:Unconjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies reactivity\u003c\/b\u003e:Human;\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e:WB\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG,κ\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Monoclonal;Recombinant\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone NO.\u003c\/b\u003e:A795\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e:P68431\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Histone post-translational modifications (PTMs) are key mechanisms of epigenetics that modulate chromatin structures, termed as “histone code”. The PTMs on histone including acetylation, methylation, phosphorylation and novel acylation directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability, gene transcription, etc. Histone phosphorylation occurs on serine, threonine and tyrosine residues on the amino-terminal of core histones. This histone mark plays roles in DNA repair, transcription and chromatin remodeling. The best-known histone phosphorylation site is histone variant H2A.x Ser139ph, which were reported to be involved in the response to DNA damage. Histone phosphorylation is mainly involved in processes during both mitosis and meiosis. Many kinases and phosphatases regulate histone phosphorylation levels.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e:1 mg\/mL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Phosphorylated human Histone H3 (Thr45) peptide\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification method\u003c\/b\u003e:Protein A purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDilution\u003c\/b\u003e:WB 1:500-1:1000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e:15 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e:15 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48644795072612,"sku":"AN302075L","price":64400.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_abb9a7ab-223d-4663-9563-bab0a74599ab.jpg?v=1782654657","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/recombinant-phospho-histone-h3-thr45-monoclonal-antibody","provider":"GeneBio ","version":"1.0","type":"link"}