{"product_id":"recombinant-human-treml2-tlt2-protein-his-tag","title":"Recombinant Human TREML2\/TLT2 Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: C6orf76;TLT2;Trem-like transcript 2 protein;Triggering receptor expressed on myeloid cells-like protein 2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: immunology\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: HEK293 Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q5T2D2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_079083.2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Trem-like transcript 2 protein, also  known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2  and TLT2, is a single-pass type I membrane protein which contains  oneIg-like V-type (immunoglobulin-like) domain. TREML2 is detected in  cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed  constitutively on CD8 T-cells and induced on CD4 T-cells after activation.  TREML2 is a cell surface receptor that may play a role in the innate and  adaptive immune response. TREML2 acts as a counter-receptor for CD276 and  interaction with CD276 on T-cells enhances T-cell activation. Murine B7-H3  specifically bound to Triggering receptor expressed on myeloid cells  (TREM)-like transcript 2 (TLT-2, TREML2). TREML2 was expressed on CD8(+) T  cells constitutively and on activated CD4(+) T cells. Stimulation with B7-H3  transfectants preferentially up-regulated the proliferation and IFN-gamma  production of CD8(+) T cells. Transduction of TREML2 into T cells resulted in  enhanced IL-2 and IFN-gamma production via interactions with B7-H3. There maybe  a direct interaction between B7-H3 and TREML2 that preferentially enhances  CD8(+) T cell activation.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Ser 268\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 28.5 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 55-60 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972954472548,"sku":"PKSH031041","price":156400.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_53b2190b-3abe-4796-b2d5-1a4b3b2c20e8.jpg?v=1772201530","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/recombinant-human-treml2-tlt2-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}