{"product_id":"recombinant-human-serpinb9-pi-9-protein-baculovirus-his-tag","title":"Recombinant Human SERPINB9\/PI-9 Protein (Baculovirus, His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: CAP3;Cytoplasmic antiproteinase 3;PI-9;Peptidase inhibitor 9;Serpin B9\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Cell biology;immunology\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P50453\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: P50453\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: SerpinB9;  also known as Cytoplasmic antiproteinase 3; CAP-3; Peptidase inhibitor 9;  SERPINB9 and PI-9; is a cytoplasm protein which belongs to theserpin  family and Ov-serpin subfamily. Serpin-B9 ( CAP-3 \/ PI-9 ) is the only known  human intracellular inhibitor of granzyme B (GrB); the effector molecule in  immunity against cytomegalovirus (CMV) and in renal allograft rejection.  Serpin-B9 and SPI-6 expression in immune-privileged cells; APCs; and CTLs  protects these cells against the actions of granzyme B; and when expressed in  tumor cells or virally infected hepatocytes; confers resistance to killing by  CTL and NK cells. Expression of increasing levels of Serpin-B9 ( CAP-3 \/ PI-9 )  in target cells may progressively inhibit immune surveillance by blocking NK  and CTL-induced cytotoxicity through the perforin \/ granzyme pathway and then  through the Fas \/ FasL pathway. Serpin-B9 ( CAP-3 \/ PI-9 ) is selectively  up-regulated in hepatocytes in response to infiltration of the liver by NK  cells that express perforin and enzymatically active granzyme B. Upregulated  expression of Serpin-B9 ( CAP-3 \/ PI-9 ) in NSCLC cells may serve to protect  them from apoptosis induced by GrB.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Glu 2-Pro 376\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 44.5 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 43 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972846633060,"sku":"PKSH030777","price":155400.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_508df153-065f-482b-8720-8cece8c2abcf.jpg?v=1772200135","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/recombinant-human-serpinb9-pi-9-protein-baculovirus-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}