{"product_id":"recombinant-human-ptpn2-ptpt-protein-his-gst-tag","title":"Recombinant Human PTPN2\/PTPT Protein (His \u0026 GST Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: PTN2;PTPT;TC-PTP;TCELLPTP;TCPTP\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: Enzyme\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His-GST\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P17706\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: P17706-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Tyrosine-protein phosphatase  non-receptor type 2; also known as T-cell protein-tyrosine phosphatase; PTPN2  and PTPT; is a cytoplasm protein which belongs to theprotein-tyrosine  phosphatase family and Non-receptor class 1 subfamily. Members of the protein  tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif;  which is essential for the catalytic activity. TC-PTP \/ PTPN2 is a cytosolic  tyrosine phosphatase that functions as a negative regulator of a variety of  tyrosine kinases and other signaling proteins. The expression of TC-PTP \/ PTPN2  plays a role of tumor suppressor and may modulate response to treatment. PTPs  are known to be signaling molecules that regulate a variety of cellular  processes including cell growth; differentiation; mitotic cycle; and oncogenic  transformation. Epidermal growth factor receptor and the adaptor protein Shc  were reported to be substrates of this PTP; which suggested the roles in growth  factor mediated cell signaling. TC-PTP \/ PTPN2 is an enzyme that is essential  for the proper functioning of the immune system and that participates in the  control of cell proliferation; and inflammation.TC-PTP \/ PTPN2 was  identified as a negative regulator of NUP214-ABL1 kinase activity.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate, R\u0026amp;D Systems, Catalog # ES006. The specific activity is \u0026gt; 20 nmoles\/min\/μg. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Asn 314\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Supplied as sterile solution of 20mM Tris, 300mM NaCl, 10% glycerol, pH 8.0\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Not Applicable\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 64.4 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 60 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47973035180132,"sku":"PKSH031519","price":174500.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_031a7fe5-df33-4d0e-9487-5f32c6a0b650.jpg?v=1772203888","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/recombinant-human-ptpn2-ptpt-protein-his-gst-tag","provider":"GeneBio ","version":"1.0","type":"link"}