{"product_id":"recombinant-human-map4k2-gc-kinase-protein-his-gst-tag","title":"Recombinant Human MAP4K2\/GC Kinase Protein (His \u0026 GST Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: BL44;GCK;MAP4K2;RAB8IP\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His-GST\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q12851\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: AAH47865.1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Mitogen-activated protein kinase  kinase kinase kinase 2, also known as B lymphocyte serine\/threonine-protein  kinase, Germinal center kinase, MAPK\/ERK kinase kinase kinase 2, MEK kinase  kinase 2, Rab8-interacting protein and MAP4K2, is a cytoplasm and peripheral  membrane protein which belongs to theprotein kinase superfamily, STE  Ser\/Thr protein kinase family and STE20 subfamily. MAP4K2 contains oneCNH  domain and oneprotein kinase domain. Although this kinase is found in  many tissues, its expression in lymphoid follicles is restricted to the cells  of germinal centre, where it may participate in B-cell differentiation. MAP4K2  can be activated by TNF-alpha, and has been shown to specifically activate MAP  kinases. It is also found to interact with TNF receptor-associated factor 2  (TRAF2), which is involved in the activation of MAP3K1 \/ MEKK1. MAP4K2 enhances  MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1  autoinhibition and lead to activation following autophosphorylation. It may  also play a role in the regulation of vesicle targeting or fusion.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Tyr 812\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 87 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Supplied as sterile solution of 50mM Tris, 100mM NaCl, pH 8.0\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Not Applicable\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 119 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 116 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972819107940,"sku":"PKSH030347","price":132500.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_ee18ab8b-bfd8-4c14-a89b-7aad807b8a43.jpg?v=1772197832","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/recombinant-human-map4k2-gc-kinase-protein-his-gst-tag","provider":"GeneBio ","version":"1.0","type":"link"}