{"product_id":"recombinant-human-ccl25-protein-sumo-tag","title":"Recombinant Human CCL25 Protein(Sumo Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e:This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e:12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e:Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e:Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e:CCL25\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e:A130072A22Rik;C-C motif chemokine 25;CCL 25;CCL25;CCL25;Chemokine (C C motif) ligand 25;Chemokine (CC motif) ligand 25;Chemokine C C motif ligand 25;Chemokine CC motif ligand 25;Chemokine TECK;Ck beta 15;Ckb 15;Ckb15;MGC125074;MGC150327;SCY A25;SCYA 25;SCYA25;Small inducible cytokine A25;Small inducible cytokine A25 isoform 1 precursor;Small inducible cytokine A25 isoform 2 precursor;Small inducible cytokine subfamily A (Cys Cys) member 25;Small inducible cytokine subfamily A Cys Cys member 25;Small inducible cytokine subfamily A;member 25;Small-inducible cytokine A25;TECK;TECKvar;Thymus expressed chemokine;Thymus-expressed chemokine\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Immunology\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e:E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e:N-Sumo\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e:O15444\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e:O15444\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:CCL25, also known as TECK (thymus-expressed chemokine), is a CC chemokine that regulates the trafficking of lymphocytes in the thymus and small intestine. Mature mouse CCL25 shares 40% and 81% amino acid sequence identity with an human and rat CCL25, respectively . CCL25 is produced by stromal cells in the thymus and epithelial cells of the small intestine, particularly the jejunum and ileum . It binds to and induces chemoattraction through CCR9 , and both human and mouse proteins act on human CCR9 . CCR9 is expressed on immature pre-T cells and thymocytes . CCL25 induces the homing of several lymphocyte populations to the small intestine , including Integrin alpha 4 beta 7+ gamma δ T cells , Integrin alpha E beta 7+ CD8+ T cells , and IgA-producing plasma cells . In cancer, functional CCR9 mediates the metastasis of melanoma cells to the small intestine , contributes to the CCL25-dependent migration and invasion of some breast carcinomas , and attracts mesenchymal stromal cells to CCL25-expressing multiple myelomas . CCL25 contributes to the severity of chronic inflammation in rheumatoid arthritis where it attracts CCR9+ monocytes and macrophages , in endometriosis where it promotes the invasiveness of stromal cells , and in atherosclerosis where it contributes to the accumulation of CCR9+ macrophages in arterial plaques .\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e:Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e:Gln24-Leu150\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e: \u0026gt; 90% as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e:Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e:It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg\/mL. Concentration is measured by UV-Vis.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:\u0026lt; 10 EU\/mg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e:26.8 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e:34 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48644020109412,"sku":"PDEH100520","price":154400.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_9be9397e-152c-484c-a10f-348c33766f03.jpg?v=1782608185","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/recombinant-human-ccl25-protein-sumo-tag","provider":"GeneBio ","version":"1.0","type":"link"}