{"product_id":"recombinant-human-bcl-2-protein","title":"Recombinant Human Bcl-2 protein","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:5 ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:B-cell lymphoma 2 (Bcl-2) is the founding member of the Bcl-2 family and it is encoded by the BCL2 gene in human. Bcl-2\nforms homodimer and heterodimers with other Bcl-2 family proteins, like BAX, BAK, BAD and Bcl-xL. Alternative splicing of\nBcl-2 results in two isoforms with similar folds despite differences in anti-apoptotic activity. Bcl-2 suppresses apoptosis by\ncontrolling the mitochondrial membrane permeability. It inhibits caspase activity either by preventing the release of cytochrome c\nfrom the mitochondria and\/or by binding to the apoptosis-activating factor (APAF-1). Antibodies to Bcl-2 can be used with\nimmunohistochemistry to identify cells containing the antigen. In some cases, the presence or absence of Bcl-2 staining in\nbiopsies may be significant for the patients prognosis or likelihood of cancer relapse. Mature human Bcl-2 shares 88 % - 90 %\namino acid sequence identity with Mouse, rat, bovine, canine Bcl-2.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e: Cell Biology\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:0\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSource\u003c\/b\u003e:0\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFull product name\u003c\/b\u003e:Recombinant Human B-cell Lymphoma 2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBiological activity\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:Bcl-2,PPP1R5,BCL2, Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:Less than 0.1 EU\/μg of rHuBcl-2 as determined by LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:-20ºC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e:AHAGRTGYDN REIVMKYIHY KLSQRGYEWD AGDVGAAPPG AAPAPGIFSS\nQPGHTPHPAA SRDPVARTSP LQTPAAPGAA AGPALSPVPP VVHLTLRQAG\nDDFSRRYRRD FAEMSSQLHL TPFTARGRFA TVVEELFRDG VNWGRIVAFF\nEFGGVMCVES VNREMSPLVD NIALWMTEYL NRHLHTWIQD NGGWDAFVEL\nYGPSMRPLFD\u003c\/p\u003e\u003cp\u003e\u003cb\u003euniprot accession\u003c\/b\u003e:O6238\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMolecular weight\u003c\/b\u003e:Approximately 23.2 kDa, a single non-glycosylated polypeptide chain containing 21 amino acids.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e:.2 μm filtered concentrated solution in 25 mM Tris-HCl, pH 8., 1mM NaCl, 1 mM DTT, 3 %\nGlycerol, with Tween-8.\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48654040334436,"sku":"CD02276","price":59400.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_e56a3c14-9bc2-4981-8fe4-d1ef1961795b.jpg?v=1782768558","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/recombinant-human-bcl-2-protein","provider":"GeneBio ","version":"1.0","type":"link"}