{"product_id":"recombinant-human-14-3-3-tau-14-3-3-theta-ywhaq-protein-gst-tag","title":"Recombinant Human 14-3-3 tau\/14-3-3 theta\/YWHAQ Protein (GST Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: 1C5;41701;HS1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction;Neuroscience;Stem cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-GST\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P27348\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: P27348\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: G protein-coupled receptor kinase 5,  also known as G protein-coupled receptor kinase GRK5 and GRK5, is a member of  the protein kinase superfamily, AGC Ser\/Thr protein kinase family and GPRK  subfamily. GRKs specifically phosphorylate agonist-occupied G protein-coupled  receptors at the inner surface of the plasma membrane (PM), leading to receptor  desensitization. GRKs utilize a variety of mechanisms to bind tightly, and  sometimes reversibly, to cellular membranes. GRKs play an important role in  mediating agonist-specific desensitization of numerous G protein-coupled  receptors.   GRK5 contains oneAGC-kinase  C-terminal domain, oneprotein kinase domain and oneRGS domain. GRK5  specifically phosphorylates the activated forms of G protein-coupled receptors.  Phospholipid-stimulated autophosphorylation may represent a novel mechanism for  membrane association and regulation of GRK5 activity. GRK5 deficiency  significantly exaggerates microgliosis and astrogliosis in the presence of an  inflammatory initiator, such as the excess fibrillar Abeta and the subsequent  active inflammatory reactions. GRK5 deficiency has been linked to early  Alzheimer's disease in humans and mouse models of the disease.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Asn 245\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 88 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile 20mM Tris, 0.15m NaCl, 20mM GSH, pH 7.5\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 54.6 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 53 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47973022695524,"sku":"PKSH031392","price":155700.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_07f6631b-1ba7-4677-b6e8-83d2e3febf1a.jpg?v=1772203257","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/recombinant-human-14-3-3-tau-14-3-3-theta-ywhaq-protein-gst-tag","provider":"GeneBio ","version":"1.0","type":"link"}