{"product_id":"recombinant-blys-tnfsf13b-baff-monoclonal-antibody","title":"Recombinant BLyS\/TNFSF13B\/BAFF Monoclonal Antibody","description":"\u003cp\u003e\u003cb\u003eSize:\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e:Ice bag\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e:12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e:Primary Antibodies\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e:Recombinant Antibodies\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e:TNFSF13B\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e:UNQ;PRO;ZTNF;TNF- and APOL-related leukocyte expressed ligand;TNFSF;TNFSF13B;BAFF;BLYS;CD257;DTL;TALL-1;TALL1;THANK;TNFSF20;TNLG7A;ZTNF4;Tumor necrosis factor ligand superfamily member 13B;B lymphocyte stimulator;B-cell-activating factor;Dendritic cell-derived TNF-like molecule;TNF- and APOL-related leukocyte expressed ligand 1;UNQ401;PRO738;BAFF;TNFSF13b;TALL-1;ApoL related ligand TALL 1;B cell Activating Factor;CD 257;CD257 antigen;Delta BAFF;Dendritic cell derived TNF like molecule;DTL precursor;soluble form;TALL 1;TN13B;TNF and APOL related leukocyte expressed ligand 1;TNF homolog that activates apoptosis;TNF homolog that activates apoptosis NKFB and JNK.;Tumor necrosis factor (ligand) superfamily member 13b;Tumor necrosis factor ligand 7A;Tumor necrosis factor ligand superfamily member 20;Tumor necrosis factor like protein ZTNF4;Tumor necrosis factor superfamily member 13B\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cell Biology;Immunology;Cancer\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e:Unconjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e:WB;FCM;IP\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Rabbit Monoclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone NO.\u003c\/b\u003e:7B3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e:Q9Y275\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:BAFF, a member of the TNF superfamily of proteins, is a homotrimeric transmembrane protein, which is cleaved to produce a soluble cytokine. BAFF may also further oligomerize into 60-mer structures. BAFF is expressed by monocytes, neutrophils, macrophages, dendritic cells, activated T cells, and epithelial cells. BAFF plays a key role in B cell development, survival, and activation. BAFF binds to three distinct receptors, BAFF-R, TACI, and BCMA. These receptors are differentially expressed during B cell development and among B cell subsets. While BAFF-R and BCMA bind to the homotrimeric form of BAFF, TACI only binds to membrane bound or higher order BAFF structures. The BAFF\/ BAFF-R interaction activates both canonical and non-canonical NF-κB pathways, PI3K\/Akt, and mTOR. Activation of the noncanonical NF-κB pathway via BAFF-R is negatively regulated by TRAF3. Research studies have shown that elevated levels of BAFF may exacerbate many autoimmune disorders, making it a potential therapeutic target.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e:1 mg\/mL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human BLyS \/ TNFSF13B \/ BAFF protein\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:0.2 μm filtered solution in PBS\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification method\u003c\/b\u003e:Protein A\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDilution\u003c\/b\u003e:WB 1:500-1:2000;IP 1-4 μL\/mg of lysate\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e:31 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e:31 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48644718002276,"sku":"AN300173P","price":0.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_ac97f3ce-fae8-45a0-a5df-bd756839cf6d.jpg?v=1782651838","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/recombinant-blys-tnfsf13b-baff-monoclonal-antibody","provider":"GeneBio ","version":"1.0","type":"link"}