{"product_id":"phospho-mdm4-ser367-antibody-cat-csb-pa975669","title":"Phospho-MDM4 (Ser367) Antibody - Cat. #: CSB-PA975669","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:DKFZp781B1423 antibody; Double minute 4 antibody; Double minute 4 human homolog of p53 binding protein antibody; Double minute 4 protein antibody; HDMX antibody; MDM 4 antibody; Mdm2 like p53 binding protein antibody; Mdm2-like p53-binding protein antibody; MDM4 antibody; Mdm4 p53 binding protein homolog mouse antibody; Mdm4 protein antibody; MDM4 related protein 1 antibody; Mdm4 transformed 3T3 cell double minute 4 antibody; Mdm4 transformed 3T3 cell double minute 4 p53 binding protein antibody; Mdm4 transformed 3T3 cell double minute 4 p53 binding protein mouse antibody; MDM4_HUMAN antibody; Mdmx protein antibody; MGC132766 antibody; Mouse double minute 4 homolog antibody; Mouse double minute 4 human homolog of p53 binding protein antibody; MRP 1 antibody; MRP1 antibody; p53 binding protein antibody; p53 BINDING PROTEIN MDM4 antibody; p53-binding protein Mdm4 antibody; Protein Mdm4 antibody; Protein Mdmx antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:O15151\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around phosphorylation site of serine 367 (T-I-S(p)-A-P) derived from Human MDM4.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Inhibits p53\/TP53- and TP73\/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:MDM4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Metabolism\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484048011364,"sku":"CSB-PA975669","price":134200.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_9a1ca1dc-5764-4290-b27d-b895bd824577.jpg?v=1660086938","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/phospho-mdm4-ser367-antibody-cat-csb-pa975669","provider":"GeneBio ","version":"1.0","type":"link"}