{"product_id":"mouse-nad-dependent-protein-deacetylase-sirtuin-3-sirt3-elisa-kit","title":"Mouse Nad-dependent Protein Deacetylase Sirtuin-3, SIRT3 ELISA Kit","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:96 Tests-1 Kit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:NAD-dependent protein deacetylase (PubMed: 23835326, PubMed: 17923681, PubMed: 18794531, PubMed: 21172655, PubMed: 26620563). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed: 23835326, PubMed: 17923681, PubMed: 18794531, PubMed: 21172655). Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP Synthase subunit ATP5PO (PubMed: 16790548, PubMed: 18794531, PubMed: 21172655). Contributes to the regulation of the cellular energy metabolism (PubMed: 23835326). Important for regulating tissue-specific ATP levels (PubMed: 18794531, PubMed: 24252090). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed: 23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide Synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (PubMed: 26620563).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e:Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget_protein\u003c\/b\u003e:SIRT3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e:Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay type\u003c\/b\u003e:Sandwich\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSensitivity\u003c\/b\u003e:0.047ng\/ml\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDetection range\u003c\/b\u003e:0.1-40ng\/ml\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSample type\u003c\/b\u003e:Serum, plasma or other biological fluids\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFull product name\u003c\/b\u003e:Nad-Dependent Protein Deacetylase Sirtuin-3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies\u003c\/b\u003e:Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:2-8ºC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay time\u003c\/b\u003e:1h 30m\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt accession\u003c\/b\u003e:Q8R104\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMASS(Da)\u003c\/b\u003e:36,615\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGeneID\u003c\/b\u003e:64384\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:mSIR2L3;NAD-dependent protein deacetylase sirtuin-3;Regulatory protein SIR2 homolog 3;SIR2-like protein 3;SIRT 3;SIRT3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene names\u003c\/b\u003e:SIRT3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStandard solution\u003c\/b\u003e:48ng\/ml\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48648257142884,"sku":"E2586Mo","price":128800.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_439287c1-2496-4e0b-9258-7c462b766aef.jpg?v=1782713931","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/mouse-nad-dependent-protein-deacetylase-sirtuin-3-sirt3-elisa-kit","provider":"GeneBio ","version":"1.0","type":"link"}