{"product_id":"kdm1a-antibody-cat-csb-pa525314ha01hu","title":"KDM1A Antibody - Cat. #: CSB-PA525314HA01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Amine oxidase (flavin containing) domain 2 antibody; Amine oxidase, flavin containing, 2 antibody; AOF2 antibody; BHC110 antibody; BRAF35 HDAC complex protein BHC110 antibody; BRAF35-HDAC complex protein BHC110 antibody; BRAF35\/HDAC complex, 110-kD subunit antibody; CPRF antibody; EC1 antibody; FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody; Flavin-containing amine oxidase domain-containing protein 2 antibody; KDM 1 antibody; KDM1 antibody; Kdm1a antibody; KDM1A_HUMAN antibody; KIAA0601 antibody; LSD 1 antibody; LSD1 antibody; Lysine (K) specific demethylase 1 antibody; Lysine (K) specific demethylase 1A antibody; Lysine demethylase 1A antibody; Lysine specific histone demethylase 1 antibody; Lysine specific histone demethylase 1A antibody; Lysine-specific demethylase 1 antibody; Lysine-specific demethylase 1A antibody; Lysine-specific histone demethylase 1A antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:O60341\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Lysine-specific histone demethylase 1A protein (100-150AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Histone demethylase that demethylates both \\\\\\'Lys-4\\\\\\' (H3K4me) and \\\\\\'Lys-9\\\\\\' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1\/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of \\\\\\'Thr-6\\\\\\' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated \\\\\\'Lys-370\\\\\\' of p53\/TP53 which prevents interaction of p53\/TP53 with TP53BP1 and represses p53\/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR\/GFI\/KDM1A\/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin\/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin\/CDH1 and CDN7.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, PH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:KDM1A\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486345179236,"sku":"CSB-PA525314HA01HU","price":61500.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_ecbf7714-4ab4-4c1a-9a80-936fc2530638.jpg?v=1660145154","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/kdm1a-antibody-cat-csb-pa525314ha01hu","provider":"GeneBio ","version":"1.0","type":"link"}