{"product_id":"asna1-antibody-cat-csb-pa002218esr1hu","title":"ASNA1 Antibody - Cat. #: CSB-PA002218ESR1HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:ARSA 1 antibody; ARSA antibody; ArsA arsenite transporter ATP binding homolog 1 antibody; ArsA arsenite transporter; ATP binding; E. coli; homolog of; 1 antibody; ArsA arsenite transporter; ATP-binding; homolog 1 (bacterial) antibody; ARSA I antibody; ARSA-I antibody; ARSA1 antibody; ARSAI antibody; Arsenical pump driving ATPase antibody; Arsenical pump-driving ATPase antibody; Arsenical resistance ATPase antibody; Arsenite translocating ATPase antibody; Arsenite transporting ATPase antibody; Arsenite-stimulated ATPase antibody; ASNA 1 antibody; ASNA I antibody; ASNA-I antibody; ASNA_HUMAN antibody; ASNA1 antibody; Asna1 protein  antibody; ASNAI antibody; ATPase ASNA1 antibody; GET3 antibody; Golgi to ER traffic 3 homolog antibody; hARSA-I antibody; hASNA-I antibody; MGC3821 antibody; Transmembrane domain recognition complex 40 kDa ATPase subunit antibody; Transmembrane domain recognition complex; 40kDa antibody; TRC40 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:O43681\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human ATPase ASNA1 protein (1-348AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antigen Affinity Purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:ASNA1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cell biology; Metabolism; Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486079430756,"sku":"CSB-PA002218ESR1HU","price":62000.0,"currency_code":"JPY","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_f7854128-4084-4437-b51a-f63d797f5088.jpg?v=1660140452","url":"https:\/\/www.genebiosystems.com\/en-jp\/products\/asna1-antibody-cat-csb-pa002218esr1hu","provider":"GeneBio ","version":"1.0","type":"link"}