{"product_id":"smad7-antibody-cat-csb-pa950035","title":"SMAD7 Antibody - Cat. #: CSB-PA950035","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:CRCS3 antibody; FLJ16482 antibody; hSMAD 7 antibody; hSMAD7 antibody; MAD (mothers against decapentaplegic Drosophila) homolog 7 antibody; MAD antibody; Mad homolog 7 antibody; MAD homolog 8 antibody; MAD mothers against decapentaplegic homolog 7 antibody; MADH 7 antibody; MADH 8 antibody; MADH6 antibody; MADH7 antibody; MADH8 antibody; Mothers Against Decapentaplegic Drosophila Homolog of 6 antibody; Mothers Against Decapentaplegic Drosophila Homolog of 7 antibody; Mothers against decapentaplegic homolog 7 antibody; Mothers against decapentaplegic homolog 8 antibody; Mothers against DPP homolog 7 antibody; Mothers against DPP homolog 8 antibody; SMA- AND MAD-RELATED PROTEIN 7 antibody; SMAD 7 antibody; SMAD antibody; SMAD family member 7 antibody; SMAD, mothers against DPP homolog 7 (Drosophila) antibody; SMAD, mothers against DPP homolog 7 antibody; SMAD6 antibody; Smad7 antibody; SMAD7_HUMAN antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:O15105\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Synthetic peptide of Human SMAD7\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antigen affinity purification\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:SMAD7\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling;Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483489972324,"sku":"CSB-PA950035","price":288.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_c69ee5a7-d952-4d8e-a5a7-0ea0524df368.jpg?v=1660069702","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/smad7-antibody-cat-csb-pa950035","provider":"GeneBio ","version":"1.0","type":"link"}