{"product_id":"setdb1-antibody-cat-csb-pa619960esr1hu","title":"SETDB1 Antibody - Cat. #: CSB-PA619960ESR1HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:AU022152 antibody; EC 2.1.1.43 antibody; ERG-associated protein with SET domain antibody; ESET antibody; H3 K9 HMTase 4 antibody; H3-K9-HMTase 4 antibody; H3-K9-HMTase4 antibody; Histone H3 K9 methyltransferase 4 antibody; Histone H3-K9 methyltransferase 4 antibody; Histone-lysine N-methyltransferase SETDB1 antibody; KG1T antibody; KIAA0067 antibody; KMT1E antibody; Lysine N-methyltransferase 1E antibody; MGC90670 antibody; mKIAA0067 antibody; SET domain bifurcated 1 antibody; Set domain protein; bifurcated; 1 antibody; SETB1_HUMAN antibody; Setdb1 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q15047\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Histone-lysine N-methyltransferase SETDB1 protein (1-397AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Histone methyltransferase that specifically trimethylates \\\\\\'Lys-9\\\\\\' of histone H3. H3 \\\\\\'Lys-9\\\\\\' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and\/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 \\\\\\'Lys-9\\\\\\' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone \\\\\\'Lys-9\\\\\\' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28\/TIF1B, a factor recruited by KRAB zinc-finger proteins.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antigen Affinity Purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:SETDB1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486118326372,"sku":"CSB-PA619960ESR1HU","price":287.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_be931c85-fb5b-4f4e-8288-c8a7503d1ed9.jpg?v=1660140979","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/setdb1-antibody-cat-csb-pa619960esr1hu","provider":"GeneBio ","version":"1.0","type":"link"}