{"product_id":"recombinant-human-rsk3-rps6ka2-protein-gst-tag","title":"Recombinant Human RSK3\/RPS6KA2 Protein (GST Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: HU-2;MAPKAPK1C;RSK;RSK3;S6K-alpha;S6K-alpha2;p90-RSK3;pp90RSK3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Epigenetics and Nuclear Signaling,Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: Enzyme\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-GST\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q15349\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: Q15349-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Ribosomal protein S6 kinase alpha-2,  also known as 90 kDa ribosomal protein S6 kinase 2, MAP kinase-activated  protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3,  RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein which belongs to theprotein  kinase superfamily, AGC Ser\/Thr protein kinase family and S6 kinase subfamily.  RPS6KA2 \/ RSK-3 is expressed in many tissues. Highest expression is in lung and  skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 arrest,  increased apoptosis, reduced levels of phosphorylated extracellular  signal-regulated kinase and altered other cell cycle proteins. RPS6KA2 \/ RSK-3  contains oneAGC-kinase C-terminal domain and twoprotein kinase  domains. It forms a complex with either ERK1 or ERK2 in quiescent cells. It  transiently dissociates following mitogenic stimulation. RPS6KA2 \/ RSK-3 is a  serine\/threonine kinase that may play a role in mediating the growth-factor and  stress induced activation of the transcription factor CREB. RPS6KA1, RPS6KA2,  RPS6KB1, RPS6KB2, and PDK1 are involved in several pathways central to the  carcinogenic process, including regulation of cell growth, insulin, and  inflammation.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: The specific activity was determined to be 41 nmol\/min\/mg using synthetic RSK peptide (KRRRLSSLRA) as substrate. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Leu 733\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 84 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 7.0, 20mM GSH\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Not Applicable\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 110 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 110 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972820516964,"sku":"PKSH030377","price":617.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_642e4e49-ed24-41f3-b433-5113d6ef4fc4.jpg?v=1772198005","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/recombinant-human-rsk3-rps6ka2-protein-gst-tag","provider":"GeneBio ","version":"1.0","type":"link"}