{"product_id":"recombinant-human-m-csf-csf1-protein","title":"Recombinant Human M-CSF\/CSF1 Protein","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 20μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Cytokines\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: CSF-1;CSF1;Lanimostim;M-CSF;MCSF;Macrophage Colony-Stimulating Factor 1;SCF-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Cardiovascular;immunology\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: HEK293 Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: Cell culture\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: None\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P09603\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_757349.1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Macrophage colony-stimulating factor  1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane  protein which is disulfide-linked as a homodimer  or heterodimer. Granulocyte \/ macrophage  colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production,  differentiation, and function of 2 related white cell populations of the blood,  the granulocytes and the monocytes-macrophages. M-CSF\/CSF-1 is known to  facilitate monocyte survival, monocyte-to-macrophage conversion, and  macrophage proliferation. M-CSF\/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into  macrophages or other related cell types. It binds to the Colony stimulating  factor 1 receptor. M-CSF\/CSF-1 may also be involved in development of the  placenta. The active form of M-CSF\/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound  precursors. M-CSF\/CSF-1 induces cells of the monocyte\/macrophage  lineage. It also plays a role in immunological defenses, bone metabolism,  lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF\/CSF-1 in the infarcted  myocardium may have an active role in healing not only through its effects on  cells of monocyte\/macrophage lineage, but also by  regulating endothelial cell chemokine expression.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is typically 1. 6-6. 3 ng\/mL. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Asn190\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 85 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4. 5% Trehalose, 5% Mannitol, 0.01% Tween 80\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 18.4 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: \u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47978855563364,"sku":"PKSH031969","price":349.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_9f356321-4d2d-41d7-b748-b45e69b2d330.jpg?v=1772293815","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/recombinant-human-m-csf-csf1-protein","provider":"GeneBio ","version":"1.0","type":"link"}