{"product_id":"recombinant-human-il-8-cxcl8-protein-e-coli","title":"Recombinant Human IL-8\/CXCL8 Protein (E.coli)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Cytokines\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: IL-8\/CXCL8\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: CXCL;Interleukin;C-X-C motif chemokine;Chemokine (C-X-C motif) ligand;IL8\/CXCL;GCP;NAP;CXCL8;GCP-1;GCP1;IL8;LECT;LUCT;LYNAP;MDNCF;MONAP;NAF;NAP-1;NAP1;3-10C;AMCF-I;IL8\/CXCL8;K60;Interleukin-8;IL-8;Emoctakin;C-X-C motif chemokine 8;Chemokine (C-X-C motif) ligand 8;Granulocyte chemotactic protein 1 (GCP-1);Monocyte-derived neutrophil chemotactic factor (MDNCF);(Ala-IL-8)77;(Ser-IL-8)72;9E3;Beta thromboglobulin like protein;CEF-4;chemokine;CXC motif;GCP\/IL-8 protein I;GCP\/IL-8 protein II;GCP\/IL-8 protein III;GCP\/IL-8 protein IV;GCP\/IL-8 protein V;GCP\/IL-8 protein VI;Granulocyte chemotactic protein 1;IL-8(1-77);IL-8(9-77);IL8\/NAP1 form I;IL8\/NAP1 form II;IL8\/NAP1 form III;IL8\/NAP1 form IV;IL8\/NAP1 form V;IL8\/NAP1 form VI;Inteleukin 8;ligand 8;Lymphocyte-derived neutrophil-activating factor;MDNCF-b;MDNCF-c;Monocyte-derived neutrophil chemotactic factor;Monocyte-derived neutrophil-activating peptide;Neutrophil activating peptide 1;Neutrophil activating protein 1;Neutrophil-activating factor;Neutrophil-activating protein 1;Protein 3 10C;Protein 3-10C;SCYB8;Small inducible cytokine subfamily B member 8;T cell chemotactic factor;T-cell chemotactic factor;TSG1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Cardiovascular;Cancer;immunology\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: None\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P10145\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_000575.1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte\/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia\/anoxia may stimulate expression. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8\/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental chang. Numerous observations have established IL-8\/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. The discovery of these biological functions suggests that IL-8\/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Ser 28-Ser 99\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4 \u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 8.5 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: \u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972814553188,"sku":"PKSH030277","price":617.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_1aa82b98-e1fa-45c7-82ad-dbca8586f9a1.jpg?v=1772197441","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/recombinant-human-il-8-cxcl8-protein-e-coli","provider":"GeneBio ","version":"1.0","type":"link"}