{"product_id":"rat-sterol-regulatory-element-binding-protein-1c-srebp-1c-elisa-kit","title":"Rat Sterol Regulatory Element-binding Protein 1C, SREBP-1C ELISA Kit","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:96 Tests-1 Kit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (By similarity).\n\nLow sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity).\n\nKey transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity).\n\nBinds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') (PubMed:7739539).\n\nHas dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity).\n\nRegulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (By similarity).\n\nIsoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity).\n\nAble to stimulate both lipogenic and cholesterogenic gene expression (By similarity).\n\nHas a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver. Required for innate immune response in macrophages by regulating lipid metabolism (By similarity).\n\nPredominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity).\n\nPrimarily controls expression of lipogenic gene (By similarity).\n\nStrongly activates global lipid synthesis in rapidly growing cells (By similarity).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e:Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget_protein\u003c\/b\u003e:SREBP-1C\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e:Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay type\u003c\/b\u003e:Sandwich\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSensitivity\u003c\/b\u003e:14.35ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDetection range\u003c\/b\u003e:30-9000ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSample type\u003c\/b\u003e:Serum, plasma or other biological fluids\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFull product name\u003c\/b\u003e:Sterol regulatory element-binding protein 1C\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies\u003c\/b\u003e:Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:2-8ºC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay time\u003c\/b\u003e:1h 30m\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt accession\u003c\/b\u003e:P56720\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMASS(Da)\u003c\/b\u003e:120,521\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGeneID\u003c\/b\u003e:78968\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:ADD1;ADD-1;Adipocyte determination- and differentiation-dependent factor 1;Processed sterol regulatory element-binding protein 1;Srebp1;SREBP-1;SREBP-1c;Sterol regulatory element-binding protein 1;Sterol regulatory element-binding transcription factor 1;Transcription factor SREBF1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene names\u003c\/b\u003e:Srebf1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStandard solution\u003c\/b\u003e:9600ng\/L\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48648342339684,"sku":"E2265Ra","price":600.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_9660bf62-db92-4234-ac5d-579f42a007cd.jpg?v=1782715925","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/rat-sterol-regulatory-element-binding-protein-1c-srebp-1c-elisa-kit","provider":"GeneBio ","version":"1.0","type":"link"}