{"product_id":"phospho-prkaa1-prkaa2-ser487-antibody-cat-csb-pa261465","title":"Phospho-PRKAA1\/PRKAA2 (Ser487) Antibody - Cat. #: CSB-PA261465","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:5 AMP activated protein kinase alpha 1catalytic subunit antibody; 5 AMP activated protein kinase catalytic alpha 1 chain antibody; 5' AMP activated protein kinase catalytic subunit alpha 1 antibody; 5'-AMP-activated protein kinase catalytic subunit alpha-1 antibody; AAPK1 antibody; AAPK1_HUMAN antibody; ACACA kinase antibody; acetyl CoA carboxylase kinase antibody; AI194361 antibody; AI450832 antibody; AL024255 antibody; AMP -activate kinase alpha 1 subunit antibody; AMP-activate kinase alpha 1 subunit\t antibody; AMP-activated protein kinase, catalytic, alpha -1 antibody; AMPK 1 antibody; AMPK alpha 1 antibody; AMPK alpha 1 chain antibody; AMPK antibody; AMPK subunit alpha 1 antibody; AMPK subunit alpha-1 antibody; AMPK1 antibody; AMPKa1 antibody; AMPKalpha1 antibody; C130083N04Rik antibody; cb116 antibody; EC 2.7.11.1 antibody; HMG CoA reductase kinase antibody; HMGCR kinase antibody; hormone sensitive lipase kinase antibody; Hydroxymethylglutaryl CoA reductase kinase antibody; im:7154392 antibody; kinase AMPK alpha1 antibody; MGC33776 antibody; MGC57364 antibody; OTTHUMP00000161795 antibody; OTTHUMP00000161796 antibody; PRKAA 1 antibody; PRKAA1 antibody; Protein kinase AMP activated alpha 1 catalytic subunit antibody; SNF1-like protein AMPK antibody; SNF1A antibody; Tau protein kinase PRKAA1 antibody; wu:fa94c10 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q13131\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around phosphorylation site of serine 487 (S-G- SP-V-S) derived from Human AMPKa1.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003eResponsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and\/or hypoxia. This is a catalytic subunit.  \u003cbr\u003e\u003cbr\u003eKim JE, et al. (2005) J Proteome Res. 4(4): 1339-1346. \u003cbr\u003eWoods A, et al. (2003) J Biol Chem. 278(31): 28434-28442.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Supplied at 1.0mg\/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:PRKAA1\/PRKAA2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Neuroscience?Cancer?Cardiovascular;Metabolism;Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484054007908,"sku":"CSB-PA261465","price":616.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_592a6962-844f-4d4d-9955-4312a5e8c6f6.jpg?v=1660087125","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/phospho-prkaa1-prkaa2-ser487-antibody-cat-csb-pa261465","provider":"GeneBio ","version":"1.0","type":"link"}