{"product_id":"phospho-pin1-ser16-antibody-cat-csb-pa801966","title":"Phospho-PIN1 (Ser16) Antibody - Cat. #: CSB-PA801966","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:DOD antibody; DODO, Drosophila, homolog of antibody; FLJ40239 antibody; FLJ77628 antibody; MGC10717 antibody; NIMA interacting 1 antibody; Peptidyl prolyl cis trans isomerase NIMA interacting 1 antibody; Peptidyl prolyl cis\/trans isomerase NIMA interacting antibody; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody; Peptidyl-prolyl cis-trans isomerase pin1 antibody; Peptidylprolyl cis\/trans isomerase NIMA interacting 1 antibody; Pin 1 antibody; Pin1 antibody; PIN1_HUMAN antibody; PPIase Pin1 antibody; Prolyl isomerase antibody; Protein (peptidylprolyl cis\/trans isomerase) NIMA interacting 1 antibody; Protein NIMA interacting 1 antibody; Rotamase Pin1 antibody; UBL 5 antibody; UBL5 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q13526\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around phosphorylation site of serine16(R-M-S(p)-R-S) derived from Human  Pin1 .\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; WB:1:500-1:1000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003eEssential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer\/Thr-Pro cis\/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.\u003cbr\u003e\u003cbr\u003eLee YC, et al. (2013)J Cell Sci 126, 4862-72.                   Ando K, et al. (2013)Neurobiol Aging 34, 757-69.     Nechama M, Lin CL, Richter JD (2013)Mol Cell Biol 33, 48-58.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:PIN1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Neuroscience;Cell biology\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484026876004,"sku":"CSB-PA801966","price":621.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_bd8fb370-2aa6-4944-b30c-325621a4d044.jpg?v=1660086369","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/phospho-pin1-ser16-antibody-cat-csb-pa801966","provider":"GeneBio ","version":"1.0","type":"link"}