{"product_id":"phospho-epha2-epha3-epha4-tyr588-596-antibody-cat-csb-pa438798","title":"Phospho-EPHA2\/EPHA3\/EPHA4 (Tyr588\/596) Antibody - Cat. #: CSB-PA438798","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:ARCC2 antibody; AW545284 antibody; CTPA antibody; CTPP1 antibody; CTRCT6 antibody; EC 2.7.10.1 antibody; Eck antibody; Eph receptor A2 antibody; EPHA2 antibody; EPHA2_HUMAN antibody; Ephrin receptor  antibody; Ephrin receptor EphA2 antibody; Ephrin type A receptor 2 antibody; Ephrin type-A receptor 2 antibody; Epithelial cell kinase antibody; Epithelial cell receptor protein tyrosine kinase antibody; Myk 2 antibody; Myk2 antibody; Sek 2 antibody; Sek2 antibody; Soluble EPHA2 variant 1 antibody; Tyrosine protein kinase receptor ECK antibody; Tyrosine-protein kinase receptor ECK antibody; Tyrosine-protein kinase receptor MPK-5 antibody; Tyrosine-protein kinase receptor SEK-2 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P29317\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around phosphorylation site of tyrosine 588\/596 (K-T-Y(p)-V-R)\/(R-T-Y(p)-V-D) derived from Human EPHA2\/3\/4.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IF; WB:1:500-1:1000, IF:1:100-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003eReceptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1\/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1\/desmoglein-1 and inhibition of the ERK1\/ERK2 (MAPK3\/MAPK1, respectively) signaling pathway. \u003cbr\u003e\u003cbr\u003eLindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990).\u003cbr\u003eZhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).\u003cbr\u003eZhuang G., J. Biol. Chem. 282:2683-2694(2007)\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:EPHA2\/EPHA3\/EPHA4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Neuroscience;Cardiovascular\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484044701796,"sku":"CSB-PA438798","price":632.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_b5df5233-2b22-4d1b-b493-15aae32c5ac3.jpg?v=1660086862","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/phospho-epha2-epha3-epha4-tyr588-596-antibody-cat-csb-pa438798","provider":"GeneBio ","version":"1.0","type":"link"}