{"product_id":"phospho-adrb2-ser346-antibody-cat-csb-pa758017","title":"Phospho-ADRB2 (Ser346) Antibody - Cat. #: CSB-PA758017","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:ADRB2 antibody; ADRB2_HUMAN antibody; ADRB2R antibody; ADRBR antibody; Adrenergic beta 2 receptor surface antibody; Adrenoceptor beta 2 surface antibody; B2AR antibody; BAR antibody; beta 2 adrenoceptor antibody; Beta 2 adrenoreceptor antibody; Beta-2 adrenergic receptor antibody; Beta-2 adrenoceptor antibody; Beta-2 adrenoreceptor antibody; BETA2AR antibody; Catecholamine receptor antibody; OTTHUMP00000160386 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P07550\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Peptide sequence around phosphorylation site of serine 346 (R-S-S(p)-L-K) derived from Human Adrenergic Receptor beta2.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; WB:1:500-1:1000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003eBeta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.\u003cbr\u003e\u003cbr\u003eGao S, Malbon C, Wang HY (2014) J Mol Signal 9, 3 \u003cbr\u003e24690384   Curated Info\u003cbr\u003eVistein R, Puthenveedu MA (2013) Proc Natl Acad Sci U S A 110, 15289-94 \u003cbr\u003eGimenez LE, et al. (2012) J Biol Chem 287, 9028-40\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:ADRB2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cardiovascular;Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484027400292,"sku":"CSB-PA758017","price":621.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_ac658307-d36c-4f5e-8877-a12807a71191.jpg?v=1660086380","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/phospho-adrb2-ser346-antibody-cat-csb-pa758017","provider":"GeneBio ","version":"1.0","type":"link"}