{"product_id":"il7-antibody-cat-csb-pa011669ka01hu","title":"IL7 Antibody - Cat. #: CSB-PA011669KA01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:IL 7 antibody; IL-7 antibody; Il7 antibody; IL7_HUMAN antibody; Interleukin 7 antibody; Interleukin-7 antibody; LP-1 antibody; Lymphopoietin 1 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P13232\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant protein of Human IL7\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:IL-7 plays a key role in lymphopoiesis and lymphoid homeostasis. Stromal and epithelial cells within the bone marrow and thymus produce IL-7. The primary targets of IL-7 are T cells, B cells, and dendritic cells. IL-7 is crucial for T cell development, the importance of which is underscored by the lack of T cells in both mice and humans that are deficient in IL-7\/IL-7R signaling. While IL-7 appears to be required for B cell development in mice, the role of IL-7 in human B cell development is unclear. In addition to its effects on T cell lymphopoiesis, IL-7 promotes the maintenance and survival of naïve and memory ?? T cells, as well as ?? T cells. The IL-7 receptor is a heterodimer of the common ? chain, ?c, and the IL-7-specific IL-7R?. IL-7 activates PI3K\/Akt, Jak1\/2, and Stat1, 3, and 5.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Affinity purification\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Store at -20°C or -80°C. Avoid freeze \/ thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:IL7\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Immunology\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483675045988,"sku":"CSB-PA011669KA01HU","price":687.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_2ea9eaa5-18ca-4e48-a75f-bf998dec183e.jpg?v=1660073585","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/il7-antibody-cat-csb-pa011669ka01hu","provider":"GeneBio ","version":"1.0","type":"link"}