{"product_id":"human-glucocorticoid-receptor-nr3c1-elisa-kit","title":"Human Glucocorticoid Receptor, NR3C1 ELISA Kit","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:96 Tests-1 Kit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Receptor for glucocorticoids (GC) (PubMed: 27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed: 9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed: 25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed: 15866175, PubMed: 19248771, PubMed: 20484466, PubMed: 23820903, PubMed: 11435610, PubMed: 15769988, PubMed: 17635946, PubMed: 19141540, PubMed: 21664385). Mediates glucocorticoid-induced apoptosis (PubMed: 23303127). Promotes accurate chromosome segregation during mitosis (PubMed: 25847991). May act as a tumor suppressor (PubMed: 25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed: 7769088, PubMed: 8621628, PubMed: 20484466). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed: 19248771, PubMed: 26711253). Loses this transcription modulator function on its own (PubMed: 20484466). Has no hormone-binding activity (PubMed: 8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed: 26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed: 26711253). [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed: 20484466). [Isoform GR-P]: Increases activity of isoform Alpha. [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. [Isoform 10]: Has transcriptional activation activity. [Isoform Alpha-C1]: Has transcriptional activation activity. [Isoform Alpha-C2]: Has transcriptional activation activity. [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed: 15866175, PubMed: 23820903). Has transcriptional repression activity (PubMed: 23303127). Mediates glucocorticoid-induced apoptosis (PubMed: 23303127, PubMed: 23820903). [Isoform Alpha-D1]: Has transcriptional activation activity. [Isoform Alpha-D2]: Has transcriptional activation activity. [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed: 15866175, PubMed: 23820903). Has transcriptional repression activity (PubMed: 23303127).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget_protein\u003c\/b\u003e:NR3C1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay type\u003c\/b\u003e:Sandwich\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSensitivity\u003c\/b\u003e:9.82ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDetection range\u003c\/b\u003e:20-4500ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSample type\u003c\/b\u003e:Serum, plasma or other biological fluids\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFull product name\u003c\/b\u003e:Glucocorticoid Receptor\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:2-8ºC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay time\u003c\/b\u003e:1h 30m\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt accession\u003c\/b\u003e:P04150\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMASS(Da)\u003c\/b\u003e:85,659\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGeneID\u003c\/b\u003e:2908\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:Glucocorticoid receptor;GR;NR3C1;Nuclear receptor subfamily 3 group C member 1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene names\u003c\/b\u003e:NR3C1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStandard solution\u003c\/b\u003e:4800ng\/L\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48648123416676,"sku":"E5331Hu","price":601.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_fccbd847-3a6b-4058-8986-054d834759bb.jpg?v=1782709559","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/human-glucocorticoid-receptor-nr3c1-elisa-kit","provider":"GeneBio ","version":"1.0","type":"link"}