{"product_id":"human-e3-sumo-protein-ligase-egr2-egr2-elisa-kit","title":"Human E3 Sumo-protein Ligase Egr2, EGR2 ELISA Kit","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:96 Tests-1 Kit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Sequence-specific DNA-binding transcription factor (PubMed:17717711).\n\nPlays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity).\n\nBinds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity).\n\nBinds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity).\n\nRegulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity).\n\nPromotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity).\n\nRegulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity).\n\nInvolved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity).\n\nMay play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity).\n\nE3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget_protein\u003c\/b\u003e:Egr2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay type\u003c\/b\u003e:Sandwich\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSensitivity\u003c\/b\u003e:4.85ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDetection range\u003c\/b\u003e:10-3000ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSample type\u003c\/b\u003e:Serum, plasma or other biological fluids\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFull product name\u003c\/b\u003e:E3 SUMO-protein ligase EGR2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:2-8ºC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay time\u003c\/b\u003e:1h 30m\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt accession\u003c\/b\u003e:P11161\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMASS(Da)\u003c\/b\u003e:50,302\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGeneID\u003c\/b\u003e:1959\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:AT591;CHN1;CMT1D;CMT4E;E3 SUMO-protein ligase EGR2;E3 SUMO-protein transferase ERG2;Early growth response protein 2;Egr2;EGR-2;KROX20;Zinc finger protein Krox-20\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene names\u003c\/b\u003e:EGR2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStandard solution\u003c\/b\u003e:3200ng\/L\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48648093958244,"sku":"E3928Hu","price":602.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_25c8235b-a489-4b0a-886f-e7dea525afb9.jpg?v=1782708429","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/human-e3-sumo-protein-ligase-egr2-egr2-elisa-kit","provider":"GeneBio ","version":"1.0","type":"link"}