{"product_id":"human-cytochrome-p450-11b2-mitochondrial-aldos-elisa-kit","title":"Human Cytochrome P450 11B2, Mitochondrial, ALDOS ELISA Kit","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:96 Tests-1 Kit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone (PubMed: 11856349, PubMed: 23322723, PubMed: 1594605, PubMed: 9814506). Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone\/21-hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosterone (PubMed: 11856349, PubMed: 23322723, PubMed: 1594605, PubMed: 9814506). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin\/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin\/ferredoxin) (PubMed: 11856349, PubMed: 23322723, PubMed: 1594605, PubMed: 9814506).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e:Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget_protein\u003c\/b\u003e:CYP11B2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay type\u003c\/b\u003e:Sandwich\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSensitivity\u003c\/b\u003e:10.08ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDetection range\u003c\/b\u003e:20-6000ng\/L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSample type\u003c\/b\u003e:Serum, plasma or other biological fluids\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFull product name\u003c\/b\u003e:Cytochrome P450 11B2, Mitochondrial\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:2-8ºC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAssay time\u003c\/b\u003e:1h 30m\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt accession\u003c\/b\u003e:P19099\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMASS(Da)\u003c\/b\u003e:57,560\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGeneID\u003c\/b\u003e:1585\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:ALDOS;Aldosterone Synthase;Aldosterone-synthesizing enzyme;Corticosterone 18-monooxygenase, CYP11B2;CYP11B2;CYPXIB2;Cytochrome P450 11B2, mitochondrial;Cytochrome P-450Aldo;Cytochrome P-450C18;Steroid 11-beta-hydroxylase, CYP11B2;Steroid 18-hydroxylase\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene names\u003c\/b\u003e:CYP11B2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStandard solution\u003c\/b\u003e:6400ng\/L\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48648055849060,"sku":"E2440Hu","price":600.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_2e576700-51fd-4407-9f37-61df62d29423.jpg?v=1782707088","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/human-cytochrome-p450-11b2-mitochondrial-aldos-elisa-kit","provider":"GeneBio ","version":"1.0","type":"link"}