{"product_id":"hdac1-acetyl-lys220-rabbit-polyclonal-antibody-ab","title":"HDAC1 (Acetyl Lys220) Rabbit Polyclonal Antibody","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:100μL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.|Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A| H2B| H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation| cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.|PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.|Belongs to the histone deacetylase family. Type 1 subfamily.|subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1| HDAC2| RBBP4 and RBBP7. The core complex associates with MTA2| MBD2| MBD3| MTA1L1| CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex| or with SIN3| SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1| HDAC2| HMG20B\/BRAF35| AOF2\/LSD1| RCOR1\/CoREST and PHF21A\/BHC80. The BHC complex may also contain ZMYM2| ZNF217| ZMYM3| GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BCOR| BRMS1L| DAXX| DNMT1| EP300| HCFC1| NFE4| PCAF| PHB2| MIER1| KDM4A| MINT| NRIP1| PRDM6| RERE| SETDB1| SUV39H1| TGIF| TGIF2| UHRF1| UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Interacts with HDAC9. Component of a mSin3A corepressor complex that contains SIN3A| SAP130| SUDS3\/SAP45| ARID4B\/SAP180| HDAC1 and HDAC2. Interacts with BANP| CBFA2T3 and KDM5B. Interacts with SAP30L. Interacts with E4F1. Interacts with KFL1 (By similarity). Interacts with SV40 large T antigen.|tissue specificity:Ubiquitous| with higher levels in heart| pancreas and testis| and lower levels in kidney and brain.|\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch_area\u003c\/b\u003e:Cancer; Cell biology; Epigenetics and nuclear signaling; Cardiovascular; Stem cells \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget_protein\u003c\/b\u003e:HDAC1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eapplications\u003c\/b\u003e:WB,  ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone ID\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene Symbol\/ Name\u003c\/b\u003e:HDAC1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:-20°C for 1 year\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification\u003c\/b\u003e:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e:1 mg\/ml\u003c\/p\u003e\u003cp\u003e\u003cb\u003eMolecular weight(Da)\u003c\/b\u003e:53020\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt accession\u003c\/b\u003e:Human: Q13547; Mouse: O09106; Rat: Q4QQW4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e:HDAC1 ;Acetyl Lys220; Histone deacetylase 1; HD1; EC 3.5.1.98\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGeneID\u003c\/b\u003e:Human: 3065; Mouse: 433759; Rat: 297893\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48650164830308,"sku":"BT-AP10351","price":406.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_2b1eabb1-78a2-4911-a276-9cb138143631.jpg?v=1782729761","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/hdac1-acetyl-lys220-rabbit-polyclonal-antibody-ab","provider":"GeneBio ","version":"1.0","type":"link"}