{"product_id":"ezh2-antibody-cat-csb-pa613606esr2hu","title":"EZH2 Antibody - Cat. #: CSB-PA613606ESR2HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Enhancer of zeste 2 antibody; enhancer of zeste 2 polycomb repressive complex 2 subunit antibody; Enhancer of zeste homolog 2 (Drosophila) antibody; Enhancer of zeste homolog 2 antibody; Enhancer of zeste; Drosophila; homolog 2 antibody; ENX 1 antibody; Enx 1h antibody; ENX-1 antibody; ENX1 antibody; Enx1h antibody; EZH 2 antibody; EZH1 antibody; EZH2 antibody; EZH2_HUMAN antibody; EZH2b antibody; Histone-lysine N-methyltransferase EZH2 antibody; KMT 6 antibody; KMT6 antibody; KMT6A antibody; Lysine N-methyltransferase 6 antibody; MGC9169 antibody; WVS antibody; WVS2 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q15910\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Histone-lysine N-methyltransferase EZH2 protein (1-250AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; Recommended dilution: WB:1:500-1:5000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Polycomb group (PcG) protein. Catalytic subunit of the PRC2\/EED-EZH2 complex, which methylates \\\\\\'Lys-9\\\\\\' (H3K9me) and \\\\\\'Lys-27\\\\\\' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate \\\\\\'Lys-27\\\\\\' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2\/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2\/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1\/2-mediated repression of the transcriptional activation of PER1\/2 by the CLOCK-ARNTL\/BMAL1 heterodimer; involved in the di and trimethylation of \\\\\\'Lys-27\\\\\\' of histone H3 on PER1\/2 promoters which is necessary for the CRY1\/2 proteins to inhibit transcription.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antigen Affinity Purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:EZH2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling; Cancer\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486005702756,"sku":"CSB-PA613606ESR2HU","price":287.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_4a4faacd-8b98-4c50-b33f-36b3b5ebc69e.jpg?v=1660139409","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/ezh2-antibody-cat-csb-pa613606esr2hu","provider":"GeneBio ","version":"1.0","type":"link"}