{"product_id":"cse1l-antibody-biotin-conjugated-cat-csb-pa006042ld01hu","title":"CSE1L Antibody, Biotin conjugated - Cat. #: CSB-PA006042LD01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:CAS antibody; Cellular apoptosis susceptibility protein antibody; Chromosome segregation 1 (yeast homolog) like antibody; Chromosome segregation 1 Like antibody; Chromosome segregation 1 like protein antibody; Chromosome segregation 1-like protein antibody; Chromosome segregation gene CSE1 antibody; CSE 1 antibody; CSE 1 chromosome segregation 1 like antibody; CSE 1 chromosome segregation 1 like protein antibody; CSE 1L antibody; CSE1 antibody; CSE1 chromosome segregation 1 like (yeast) antibody; CSE1 chromosome segregation 1 like antibody; CSE1 chromosome segregation 1 like protein antibody; CSE1L antibody; Exp 2 antibody; Exp2 antibody; Exportin 2 antibody; Exportin-2 antibody; Exportin2 antibody; Importin alpha re exporter antibody; Importin-alpha re-exporter antibody; MGC117283 antibody; MGC130036 antibody; MGC130037 antibody; XPO 2 antibody; XPO2 antibody; XPO2_HUMAN antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P55060\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Exportin-2 protein (713-971AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L\/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Biotin\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:CSE1L\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cancer; Cell biology; Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40487771635812,"sku":"CSB-PA006042LD01HU","price":288.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_c4b37df9-d9bb-4259-90f8-d152a7601cc6.jpg?v=1660170712","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/cse1l-antibody-biotin-conjugated-cat-csb-pa006042ld01hu","provider":"GeneBio ","version":"1.0","type":"link"}