{"product_id":"anti-vglut2-slc17a6-antibody-picoband-r","title":"Anti-VGLUT2\/SLC17A6 Antibody Picoband®","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100 μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: At -20℃ for one year from date of receipt. \nAfter reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months.\nAvoid repeated freezing and thawing.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e: Lyophilized\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReactivity\u003c\/b\u003e: Human,Mouse,Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e: WB,ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication Details\u003c\/b\u003e: Western blot, 0.25-0.5 μg\/ml, Human, Mouse, Rat\u003cbr\u003e\nELISA, 0.1-0.5 μg\/ml, -\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene Name\u003c\/b\u003e: SLC17A6\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecificity\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Solute carrier family 17 (vesicular glutamate transporter), member 6 is a protein that in humans is encoded by the SLC17A6 gene. The SLC17A6 gene, also known as vesicular glutamate transporter 2 (VGLUT2), encodes a protein responsible for transporting the neurotransmitter glutamate into synaptic vesicles in neurons. This process is crucial for glutamatergic neurotransmission, which plays a fundamental role in synaptic communication and neuronal excitability. SLC17A6\/VGLUT2 is primarily expressed in excitatory neurons in various regions of the brain, including the cerebral cortex, hippocampus, and thalamus. Dysregulation of SLC17A6 expression or function has been implicated in neurological disorders such as epilepsy, schizophrenia, and Parkinson's disease, highlighting its significance in brain function and disease pathology. Understanding the molecular mechanisms underlying SLC17A6\/VGLUT2 function is essential for unraveling its role in normal synaptic transmission and its potential as a therapeutic target for neurological disorders.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e: E.coli-derived human VGLUT2\/SLC17A6 recombinant protein (Position: M1-K561). Human SLC17A6 shares 98.4% and 98.6% amino acid (aa) sequence identity with mouse and rat SLC17A6, respectively.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e: Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eContents\u003c\/b\u003e: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification\u003c\/b\u003e: Immunogen affinity purified.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Adding 0.2 ml of distilled water will yield a concentration of 500 μg\/ml.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReference\u003c\/b\u003e: 1. Aihara, Y., Mashima, H., Onda, H., Hisano, S., Kasuya, H., Hori, T., Yamada, S., Tomura, H., Yamada, Y., Inoue, I., Kojima, I., Takeda, J. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. J. Neurochem. 74: 2622-2625, 2000.\n2. Aihara, Y., Onda, H., Teraoka, M., Yokoyama, Y., Seino, Y., Kasuya, H., Hori, T., Tomura, H., Inoue, I., Kojima, I., Takeda, J. Assignment of SLC17A6 (alias DNPI), the gene encoding brain\/pancreatic islet-type Na(+)-dependent inorganic phosphate cotransporter to human chromosome 11p14.3. Cytogenet. Cell Genet. 92: 167-169, 2001.\n3. Bai, L., Xu, H., Collins, J. F., Ghishan, F. K. Molecular and functional analysis of a novel neuronal vesicular glutamate transporter. J. Biol. Chem. 276: 36764-36769, 2001.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniprot ID\u003c\/b\u003e: Q9P2U8\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost\u003c\/b\u003e: Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: Adding 0.2 ml of distilled water will yield a concentration of 500 μg\/ml.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eCross Reactivity\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e: IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePhospho_site\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eObserved Molecular Weight\u003c\/b\u003e: 64 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated Molecular Weight\u003c\/b\u003e: 64 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene ID\u003c\/b\u003e: 57084\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProtein Name\u003c\/b\u003e: Vesicular glutamate transporter 2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eGene Full Name\u003c\/b\u003e: solute carrier family 17 member 6\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSynonyms\u003c\/b\u003e: SLC17A6; DNPI; VGLUT2; Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48787998834788,"sku":"A04376-1","price":431.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_7dc0d256-27f3-4b66-b01d-fc7041ff88c6.jpg?v=1784406552","url":"https:\/\/www.genebiosystems.com\/en-gb\/products\/anti-vglut2-slc17a6-antibody-picoband-r","provider":"GeneBio ","version":"1.0","type":"link"}