{"product_id":"tgs1-antibody-cat-csb-pa847219la01hu","title":"TGS1 Antibody - Cat. #: CSB-PA847219LA01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Cap specific guanine N2 methyltransferase antibody; Cap-specific guanine-N2 methyltransferase antibody; CLL associated antigen KW 2 antibody; CLL-associated antigen KW-2 antibody; DKFZp762A163 antibody; FLJ22995 antibody; HCA137 antibody; Hepatocellular carcinoma associated antigen 137 antibody; Hepatocellular carcinoma-associated antigen 137 antibody; NCOA6IP antibody; Nuclear receptor coactivator 6 interacting protein antibody; Nuclear receptor coactivator 6-interacting protein antibody; PIMT antibody; PIPMT antibody; PRIP interacting protein PIPMT antibody; PRIP interacting protein with methyltransferase domain antibody; PRIP interacting protein with methyltransferase motif antibody; PRIP-interacting protein with methyltransferase motif antibody; SEREX defined antibody; TGS 1 antibody; Tgs1 antibody; TGS1_HUMAN antibody; Trimethylguanosine synthase antibody; Trimethylguanosine synthase homolog (S. cerevisiae) antibody; Trimethylguanosine synthase homolog antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q96RS0\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Trimethylguanosine synthase protein (713-853AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, PH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:TGS1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling; Cancer; Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40485697355876,"sku":"CSB-PA847219LA01HU","price":333.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_ff885cca-c9d4-445d-8f6b-0d8351825ec4.jpg?v=1660133855","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/tgs1-antibody-cat-csb-pa847219la01hu","provider":"GeneBio ","version":"1.0","type":"link"}