{"product_id":"recombinant-mouse-glo1-glyoxalase-1-protein-his-tag","title":"Recombinant Mouse GLO1\/Glyoxalase 1 Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: 0610009E22Rik;1110008E19Rik;2510049H23Rik;AW550643;GLY1;Glo-1;Glo-1r;Glo-1s;Glo1-r;Glo1-s;Qglo\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: A5GZX3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_079650.3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Lactoylglutathione lyase, also  known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde  mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the  glyoxalase I family. GLO1 \/ Glyoxalase I is a ubiquitous cellular defense  enzyme involved in the detoxification of methylglyoxal, a cytotoxic byproduct  of glycolysis. Accumulative evidence suggests an important role of GLO1  expression in protection against methylglyoxal-dependent protein adduction and  cellular damage associated with diabetes, cancer, and chronological aging. GLO1  \/ Glyoxalase I has been implicated in anxiety-like behavior in mice and in  multiple psychiatric diseases in humans. GLO1 \/ Glyoxalase I catalyzes the  conversion of hemimercaptal, formed from methylglyoxal and glutathione, to  S-lactoylglutathione. GLO1 \/ Glyoxalase I exists in three separable isoforms  which originate from two alleles in the genome. These correspond to two  homodimers and one heterodimer composed of two subunits showing different  electrophoretic properties. GLO1 upregulation may play a functional role in  glycolytic adaptations of cancer cells.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Ala 2-Ile 184\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 21.6 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 25\u0026amp;48 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47986092736612,"sku":"PKSM040716","price":936.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_8d1cf63b-1284-4bfb-bb36-6aec8da7303a.jpg?v=1772481262","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/recombinant-mouse-glo1-glyoxalase-1-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}