{"product_id":"recombinant-human-cd300a-lmir1-protein-fc-tag","title":"Recombinant Human CD300a\/LMIR1 Protein (Fc Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: CD300 Antigen-Like Family Member A;CD300A;CD300a;CLM-8;CMRF-35-H9;CMRF35-H;CMRF35-H9;CMRF35-Like Molecule 8;CMRF35H;IGSF12;IRC1\/IRC2;IRp60;IgSF12;Immunoglobulin Superfamily Member 12;Inhibitory Receptor Protein 60;NK Inhibitory Receptor\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Immunology\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: HEK293 Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-hFc\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q9UGN4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: Q9UGN4-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: CMRF35-like molecule 8; also  known as CD300 antigen-like family member A; CMRF35-H9; Immunoglobulin  superfamily member 12; Inhibitory receptor protein 60; NK inhibitory receptor;  CD300a and CMRF35H; is a single-pass type I membrane protein which belongs to  theCD300 family. The CD300 family of myeloid immunoglobulin receptors  includes activating ( CD300b; CD300e ) and inhibitory members ( CD300a; CD300f  ); as well as molecules presenting a negative charge within their transmembrane  domain ( CD300c; CD300d ). CD300A \/  IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell  subsets; B-cells; dendritic cells; mast cells; granulocytes and monocytes.It  contains oneIg-like V-type ( immunoglobulin-like ) domain. CD300A \/  IGSF12 is an inhibitory receptor which may contribute to the down-regulation of  cytolytic activity in natural killer (NK) cells; and to the down-regulation of  mast cell degranulation. CD300c is a functional immune receptor able to deliver  activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is  partially mediated by a direct association with the immune receptor  tyrosine-based activation motif-bearing adaptor FcεRγ. CD300a and CD300c play  an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion  from plasmacytoid dendritic cells (pDCs).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Gln178\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4 \u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 44.5 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 58-66 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972850466916,"sku":"PKSH030836","price":837.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_31e97e24-07d3-4661-a561-ebbc9796dfdd.jpg?v=1772200469","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/recombinant-human-cd300a-lmir1-protein-fc-tag","provider":"GeneBio ","version":"1.0","type":"link"}