{"product_id":"recombinant-human-cask-kinase-protein","title":"Recombinant Human CASK Kinase Protein","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: CAGH39;CAMGUK;CMG;FGS4;LIN2;MICPCH;MRXSNA;TNRC8\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Neuroscience,Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: None\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: O14936\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: O14936-4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Peripheral  plasma membrane protein CASK; also known as calcium\/calmodulin-dependent serine  protein kinase; CASK and LIN2; is a nucleus; cytoplasm and cell membrane  protein which belongs to theMAGUK family. CASK \/ LIN2 contains  oneguanylate kinase-like domain; twoL27 domains; onePDZ (DHR)  domain; oneprotein kinase domain and oneSH3 domain. CASK \/ LIN2 is  ubiquitously expressed. Expression of CASK \/ LIN2 is significantly greater in  brain relative to kidney; lung; and liver and in fetal brain and kidney  relative to lung and liver. CASK \/ LIN2 is a multidomain scaffolding protein  with a role in synaptic transmembrane protein anchoring and ion channel  trafficking. CASK \/ LIN2 contributes to neural development and regulation of  gene expression via interaction with the transcription factor TRB1. It binds to  cell-surface proteins; including amyloid precursor protein; neurexins and  syndecans. CASK \/ LIN2 may mediate a link between the extracellular matrix and  the actin cytoskeleton via its interaction with syndecan and with the  actin\/spectrin-binding protein 4.1. Defects in CASK are the cause of mental  retardation X-linked CASK-related (MRXCASK). Mental retardation is  characterized by significantly below average general intellectual functioning  associated with impairments in adaptative behavior and manifested during the  developmental period. Defects in CASK are also the cause of FG syndrome type 4  which is an X-linked disorder characterized by mental retardation; relative macrocephaly;  hypotonia and constipation.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Ala 2-Tyr 898\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.4 \u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 102.1 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 102 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972868915300,"sku":"PKSH030972","price":837.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_f466a670-94b0-44a8-a762-3eb72ab408d7.jpg?v=1772201162","url":"https:\/\/www.genebiosystems.com\/en-fr\/products\/recombinant-human-cask-kinase-protein","provider":"GeneBio ","version":"1.0","type":"link"}